Kanglexin, a new anthraquinone compound, attenuates lipid accumulation by activating the AMPK/SREBP-2/PCSK9/LDLR signalling pathway.

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Xin LiBaofeng Yang

Abstract

Hyperlipidaemia is one of the major risk factors for atherosclerosis, coronary heart disease, stroke and diabetes. In the present study, we synthesized a new anthraquinone compound, 1,8-dihydroxy-3-succinic acid monoethyl ester-6-methylanthraquinone, and named it Kanglexin (KLX). The aim of this study was to evaluate whether KLX has a lipid-lowering effect and to explore the potential molecular mechanism. In this study, Sprague-Dawley rats were fed a high fat diet (HFD) for 5 weeks to establish a hyperlipidaemia model; then, the rats were orally administered KLX (20, 40, and 80 mg kg-1·d-1) or atorvastatin calcium (AT, 10 mg kg-1·d-1) once a day for 2 weeks. KLX had prominent effects on reducing blood lipids, hepatic lipid accumulation, body weight and the ratio of liver weight/body weight. Furthermore, KLXdramatically reduced the total cholesterol (TC) and triglyceride (TG) levels and lipid accumulation in a HepG2 cell model of dyslipidaemia induced by 1 mmol/L oleic acid (OA). KLX may decrease lipid levels by phosphorylating adenosine monophosphate-activated protein kinase (AMPK) and the downstream sterol regulatory element binding protein 2 (SREBP-2)/proprotein convertase subtilisin/kexin type 9 (PCSK9)/low-density lipoprote...Continue Reading

References

Apr 1, 1987·Archives of Neurology·J S MeyerB W Judd
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M S Brown, J L Goldstein
Aug 10, 2000·The Journal of Pharmacy and Pharmacology·D H KuoJ T Cheng
Jun 7, 2002·The American Journal of Medicine·Antonio M Gotto
Oct 6, 2006·Medicinal Research Reviews·Qing HuangChoon Nam Ong
Jul 5, 2007·The Biochemical Journal·Jun LiJennifer L Harris
Jul 8, 2008·Biochemical and Biophysical Research Communications·Laura J Sharpe, Andrew J Brown
Jun 15, 2010·Archives of Biochemistry and Biophysics·Ryuichiro Sato
Apr 13, 2011·Handbook of Experimental Pharmacology·Benoit Viollet, Fabrizio Andreelli
Apr 21, 2011·Cold Spring Harbor Perspectives in Biology·Jin Ye, Russell A DeBose-Boyd
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·D Grahame HardieSimon A Hawley
Sep 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Satoshi Hirayama, Takashi Miida
Apr 16, 2013·Nutrients·Boudewijn KlopManuel Castro Cabezas
Jul 3, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Mfon Ewang-Emukowhate, Anthony S Wierzbicki
Nov 14, 2013·Seminars in Liver Disease·Xu XuAnn-Hwee Lee
Jul 16, 2014·Critical Reviews in Biotechnology·Jeong-Hun KangMasaharu Murata
Feb 26, 2016·Current Opinion in Lipidology·Morgan D Fullerton
Apr 26, 2016·Medicinal Research Reviews·Enas M Malik, Christa E Müller
Jul 16, 2016·Experimental & Molecular Medicine·Sang-Min Jeon
Dec 3, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Siyu ChenChang Liu
Aug 5, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Pooja MalhotraWaddah A Alrefai
Nov 21, 2017·Cell Metabolism·Sheng-Cai Lin, D Grahame Hardie
Dec 7, 2017·Recent Patents on Anti-cancer Drug Discovery·Alexander S TikhomirovAndrey E Shchekotikhin
Apr 21, 2018·Phytotherapy Research : PTR·Ki Sun KwonHyun Pyo Kim

❮ Previous
Next ❯

Citations

Apr 10, 2021·Frontiers in Cardiovascular Medicine·Aureli LuqueroMaria Borrell-Pages
May 27, 2021·Acta Pharmacologica Sinica·Hui-Min LiBao-Feng Yang
Jul 12, 2021·Atherosclerosis·Benjamin J TomblingConan K Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.