Kaposi Sarcoma-Associated Herpesvirus in a Rural Ugandan Cohort, 1992-2008

The Journal of Infectious Diseases
R NewtonDenise Whitby

Abstract

The prevalence and titers of antibodies against Kaposi sarcoma-associated herpesvirus (KSHV) in rural Africa are not completely understood, nor are their trends over time in populations in which human immunodeficiency virus (HIV) is also endemic. We examined prevalence, titers, temporal trends, and determinants of anti-KSHV antibodies in each of 3 time periods (1990-1991, 1999-2000, and 2007-2008) within a long-standing, rural population-based cohort in southwestern Uganda. For each period, we measured antibodies to the K8.1 and ORF73 KSHV antigens in approximately 3000 people of all ages (1:1 sex ratio). In all periods, KSHV prevalence increased rapidly through childhood to approximately 90% by age 15 years, plateauing at approximately 95% thereafter. Similarly, antibody titers, particularly against the lytic antigen K8.1, were among the highest seen and increased significantly with age, suggesting sustained viral replication in this population. Male sex was also independently associated with higher prevalence, whereas HIV coinfection was not. A modest reduction in prevalence among children was noted in the most recent period. KSHV seroprevalence and antibodies titers in this rural Ugandan population are the highest yet report...Continue Reading

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Citations

Jul 3, 2019·International Journal of Cancer. Journal International Du Cancer·Nazzarena LaboDenise Whitby
Oct 6, 2019·Medical Microbiology and Immunology·Juliana Prado GonçalesMaria Rosangela Cunha Duarte Coêlho
Feb 20, 2020·The Journal of Infectious Diseases·Peter O OluochAnn M Moormann
Sep 27, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Angela NalwogaRobert Newton
Jul 28, 2020·Infectious Agents and Cancer·Angela NalwogaRobert Newton
Feb 2, 2019·Nature Reviews. Disease Primers·Ethel CesarmanDenise Whitby
Oct 13, 2020·Reviews in Medical Virology·Melissa J BlumenthalGeorgia Schäfer
Nov 30, 2020·The Journal of Infectious Diseases·Katherine R SabourinRosemary Rochford

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