Kaposi sarcoma in people living with HIV: incidence and associated factors in a French cohort between 2010 and 2015.

AIDS
Isabelle Poizot-MartinDat’AIDS study group

Abstract

Kaposi sarcoma is still observed among people living with HIV (PLHIV) including those on ART with undetectable HIV viral load (HIV-VL). We aimed to assess Kaposi sarcoma incidence and trends between 2010 and 2015 in France and to highlight associated factors. Retrospective study using longitudinal data from the Dat'AIDS cohort including 44 642 PLWH. For the incidence assessment, Kaposi sarcoma cases occurring within 30 days of cohort enrollment were excluded. Demographic, immunological, and therapeutic characteristics collected at time of Kaposi sarcoma diagnosis or at last visit for patients without Kaposi sarcoma. Among 180 216.4 person-years, Kaposi sarcoma incidence was 76 (95% CI 64.3-89.9)/10 person-years. Multivariate analysis (Poisson regression) revealed the positive association with male sex, MSM transmission route, lower CD4 T-cell count, higher CD8 T-cell count, not to be on ART, whereas HIV follow-up time, duration with an HIV-VL 50 copies/ml or less were negatively associated with Kaposi sarcoma. According to the different models tested, HIV-VL, CD4 : CD8 ratio and nadir CD4 cell count were associated with Kaposi sarcoma. Moreover, stratified analysis showed that patients with a CD4 : CD8 ratio 0.5 or less or a CD...Continue Reading

References

May 11, 2005·Immunological Reviews·Rita B EffrosJanice Man
Sep 23, 2006·The Journal of Infectious Diseases·Amelie GuihotGuislaine Carcelain
Jun 3, 2009·HIV Medicine·Pascal PuglieseUNKNOWN Nadis Group
Oct 13, 2009·The Lancet Oncology·Marguerite GuiguetUNKNOWN Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort
May 6, 2010·Journal of the National Cancer Institute·Sara LodiUNKNOWN CASCADE Collaboration
Apr 25, 2012·Current HIV/AIDS Reports·Peter W Hunt
Jun 6, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Elizabeth L YanikJoseph J Eron
Aug 1, 2013·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mira HleyhelUNKNOWN French Hospital Database on HIV–ANRS CO4 Cohort
Feb 5, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcus BuggertAnnika C Karlsson
Apr 15, 2014·International Journal of Cancer. Journal International Du Cancer·Julia BohliusMatthias Egger
Dec 10, 2014·The Journal of Infectious Diseases·Marie HellebergJan Gerstoft
Aug 11, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Elizabeth L YanikEric A Engels
Oct 30, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·UNKNOWN Cancer Project Working Group for the Collaboration of Observational HIV Epidemiological Research Europe (COHERE) study in Eu
Apr 11, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Robert DubrowUNKNOWN North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Databases to Evaluate AID
Jul 13, 2017·AIDS·Fabienne Caby, UNKNOWN writing committee of the CD4+/CD8+ Ratio Working Group of the French Hospital Database on HIV (FHDH-ANRS CO4)
Aug 23, 2017·PloS One·Kathryn E RoyseElizabeth Y Chiao
Oct 12, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Eric A EngelsUNKNOWN North American AIDS Cohort Collaboration on Research and Design of the International Epidemiologic Datab
Dec 21, 2017·Clinical and Molecular Allergy : CMA·Maria Teresa VenturaRosalba Buquicchio

❮ Previous
Next ❯

Citations

Mar 21, 2021·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Pablyanne Tereza Louzada GuedesHélder Antônio Rebelo Pontes

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Cutis
Elizabeth K Satter
Nature Reviews. Disease Primers
American Family Physician
J H Hughes, D B Stoll
Medicine
R W MartinE R Farmer
© 2021 Meta ULC. All rights reserved