Kaposi's sarcoma-associated herpesvirus infection of blood endothelial cells induces lymphatic differentiation

Virology
Patrick A CarrollMichael Lagunoff

Abstract

Kaposi's sarcoma-associated herpesvirus (KSHV) is necessary for KS, a highly vascularized tumor predominated by endothelial-derived spindle cells that express markers of lymphatic endothelium. Following KSHV infection of TIME cells, an immortalized human dermal microvascular endothelial cell (DMVEC) line, expression of many genes specific to lymphatic endothelium, including VEGFR3, podoplanin, LYVE-1, and Prox-1, is significantly increased. Increases in VEGFR3 and podoplanin protein are also demonstrated following latent infection. Examination of cytokine secretion showed that KSHV infection significantly induces hIL-6 while strongly inhibiting secretion of IL-8, a gene product that is decreased by differentiation of blood to lymphatic endothelial cells. These studies support the hypotheses that latent KSHV infection of blood endothelial cells drives their differentiation to lymphatic endothelial cells.

References

Jun 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A OxholmK Bendtzen
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Apr 22, 1993·International Journal of Cancer. Journal International Du Cancer·H R WabingaJ W Mugerwa
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J RussoP S Moore
Sep 17, 1999·The Journal of Biological Chemistry·S MarchiòF Bussolino
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Young-Kwon HongGuillermo Oliver
Jan 25, 2003·Annals of the New York Academy of Sciences·Guillermom Oliver, Natasha Harvey
Mar 17, 2004·Molecular Cell·Britt Glaunsinger, Don Ganem

❮ Previous
Next ❯

Citations

Sep 23, 2014·Viruses·Shuhei Sakakibara, Giovanna Tosato
Oct 29, 2005·Journal of Virology·Lei Chen, Michael Lagunoff
Feb 3, 2007·Infectious Agents and Cancer·Pawan PyakurelPeter Biberfeld
Sep 13, 2008·PLoS Pathogens·Andrea Luísa Suárez, Linda Faye van Dyk
Jan 19, 2010·Genes & Development·Amy HansenChris Boshoff
Apr 7, 2010·The Journal of Clinical Investigation·Don Ganem
Oct 5, 2010·Genes & Development·Yingdi Wang, Guillermo Oliver
Mar 16, 2011·Antimicrobial Agents and Chemotherapy·Soren GanttJeffrey Vieira
Jul 20, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Shuhei Sakakibara, Giovanna Tosato
Apr 12, 2011·Pathology Oncology Research : POR·Nilufer Onak KandemirSukru Oguz Ozdamar
Jun 1, 2011·Advances in Virology·Fengchun YeShou-Jiang Gao
Aug 26, 2010·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Shuko OeYasuhiro Udagawa
May 10, 2005·Expert Review of Anticancer Therapy·Tony DhillonMark Bower
Aug 23, 2011·Methods : a Companion to Methods in Enzymology·Jennifer A CorcoranCraig McCormick
Feb 9, 2010·Oral Oncology·Velia Ramírez-AmadorGuillermo Martínez-Mata
Sep 21, 2007·The Journal of Investigative Dermatology·Marion GrögerPeter Petzelbauer
May 1, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Luigi RossielloRaffaele Rossiello
Sep 17, 2015·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Rosamar Eulira Fontes RezendeJosé Luiz Pimenta Módena
Jul 10, 2009·International Journal of Cancer. Journal International Du Cancer·Thomas F Schulz
Apr 15, 2006·International Journal of Cancer. Journal International Du Cancer·Pawan PyakurelPeter Biberfeld
Mar 6, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G StalloneL Gesualdo
Jan 30, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·V Ramírez-AmadorO P de Almeida
Oct 1, 2014·Clinical and Experimental Dermatology·E AgiusS R Hoque
Jun 15, 2013·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Bruno Augusto Benevenuto de AndradeOslei Paes de Almeida

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.