Kaposi's sarcoma triggered by endogenous HHV-8 reactivation after non-myeloablative allogeneic haematopoietic transplantation

European Journal of Haematology
Benedetto BrunoMario Boccadoro

Abstract

Human herpesvirus 8 (HHV-8) is causally associated with Kaposi's sarcoma (KS). KS is most frequently observed in HIV patients and in solid organ transplant recipients. The role of HHV-8 in allogeneic haematopoietic cell transplantation (HCT) remains to be determined. Here we describe a case in which KS concomitantly occurred with CMV reactivation after a non-myeloablative allogeneic HCT and presented with skin lesions, but not visceral involvement. Skin biopsy confirmed the diagnosis and ruled out graft versus host disease or disease recurrence. Molecular findings indicated viral reactivation of the recipient's primary infection. Tumour lesions completely receded when immunosuppression was tapered. Prevalence studies in donors and recipients are needed to determine the clinical impact of HHV-8 in HCT.

References

Mar 2, 1997·Bone Marrow Transplantation·B ErerD Baronciani
Oct 6, 1997·Transplantation·I Penn
Apr 2, 1998·The New England Journal of Medicine·J N MartinD H Kedes
Jun 17, 1998·Journal of Virology·C DiamondL Corey
Jul 29, 1998·The Journal of General Virology·T F Schulz
Apr 3, 1999·The New England Journal of Medicine·C FrancèsV Calvez
Jun 4, 1999·Trends in Microbiology·T F Schulz, P S Moore
Sep 1, 1999·Bone Marrow Transplantation·M RosenzwajgJ Gluckman
Apr 4, 2000·Journal of Clinical Microbiology·F LallemandV Marechal
Nov 9, 2000·The New England Journal of Medicine·J PaukL Corey
Nov 9, 2000·The New England Journal of Medicine·M LuppiG Torelli
Nov 9, 2000·The New England Journal of Medicine·P S Moore
Jun 26, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B EnsoliP Monini
Mar 12, 2002·JAMA : the Journal of the American Medical Association·Massimo AndreoniGiovanni Rezza
Apr 15, 2003·Nature Medicine·Patrizia BarozziGiuseppe Torelli
Jun 28, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael J CannonPhilip E Pellett
Aug 2, 2003·International Journal of Dermatology·Sara Isabel PalenciaLuis Iglesias-Díez
Aug 9, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mario LuppiGiuseppe Torelli
Jan 26, 2005·British Journal of Cancer·D SerrainoG Busnach
Jul 7, 2005·Journal of the National Cancer Institute·Giuseppe GentilePietro Martino

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Citations

Jul 14, 2011·Leukemia & Lymphoma·Irit AviviTsila Zuckerman
Sep 13, 2012·Blood·Giovanni RivaLeonardo Potenza
Sep 30, 2010·Cell Transplantation·Mariagrazia MichieliPaolo De Paoli
Sep 8, 2011·International Ophthalmology Clinics·Anthony B DanielsLucy H Y Young
Sep 15, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Marcie TomblynUNKNOWN Centers for Disease Control and Prevention
Oct 26, 2021·Current Opinion in Infectious Diseases·Malgorzata MikulskaAlessandra Mularoni

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