PMID: 2510129Oct 25, 1989Paper

kappa B elements strongly activate gene expression in non-lymphoid cells and function synergistically with NF1 elements

Nucleic Acids Research
L HennighausenC W Pittius

Abstract

kappa B elements have been described as lymphoid-specific transcriptional activators. Here we show that kappa B elements are able to stimulate expression from test promoters more than 100-fold in T47D and 3T3 non-lymphoid cells. We also demonstrate that nuclear proteins from T47D cells form two prominent complexes with HIV kappa B sites. Since the complexes formed in nuclear extracts from T47D and PHA/PMA stimulated Jurkat cells comigrate in polyacrylamide gels, we suggest that the respective binding protein in T47D cells is either NF-kappa B or a closely related family member. In addition we provide evidence that NF1 and kappa B elements can act synergistically to further increase transcriptional activity.

References

Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C W PittiusK Gordon
Oct 1, 1988·AIDS Research and Human Retroviruses·H LubonL Hennighausen
Mar 11, 1987·Nucleic Acids Research·H Lubon, L Hennighausen
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GhazalL Hennighausen
Jan 1, 1987·AIDS Research and Human Retroviruses·R PatarcaU M Hansen
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J W PierceD Baltimore
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·A S Baldwin, P A Sharp
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S E Tong-StarksenB M Peterlin

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