Abstract
We aimed to further define the pathway mediating the inhibitory effects of kappa-opioid receptor stimulation on Ca(2+) transients and hypertrophic responses to beta(1)-adrenoceptor stimulation. We determined the effects of trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]-benzeneacetamid methanesulfonate salt (U50,488H), a selective kappa-opioid receptor agonist, on the enhancement of spontaneous Ca(2+) transients and the induction of hypertrophy by isoprenaline, a beta-adrenoceptor agonist, in cultured neonatal ventricular myocytes. The results were compared with those found with KN93, a selective Ca(2+)/calmodulin-dependent kinase (CaMKII) inhibitor, propranolol, a beta-adrenoceptor antagonist, and verapamil, a L-type Ca(2+) channel antagonist. Hypertrophy of cardiomyocytes was characterized by increases in (i) total protein content; (ii) cell size; and (iii) [(3)H]leucine incorporation. 10 micromol/l isoprenaline increased all three parameters. We also determined the expression of nuclear CaMKIIdelta in response to U50,488H in the presence or absence of isoprenaline. To determine whether the effects of U50,488H were receptor-mediated, its effects were also measured following blockade of the kappa-opioid rec...Continue Reading
References
Jan 1, 1992·Circulation Research·C VenturaM C Capogrossi
Jan 1, 1992·Life Sciences·K K TaiT M Wong
Jan 1, 1990·Hypertension·M C LaPointeD G Gardner
Jan 15, 1990·Experientia·J S KarlinerP C Simpson
Mar 1, 1990·Peptides·R B RothmanL S Brady
Apr 1, 1989·Hypertension·B C BerkT Tsuda
Jan 1, 1989·Life Sciences·F C TortellaJ W Holaday
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R S ZukinA Tempel
Mar 30, 1987·Life Sciences·P S PortogheseA E Takemori
Jan 1, 1982·Circulation Research·P Simpson, S Savion
Jan 1, 1995·Advances in Second Messenger and Phosphoprotein Research·D L Campbell, H C Strauss
Dec 3, 1993·Cell·J SadoshimaS Izumo
Jul 1, 1993·Endocrinology·C L GruverA R Means
Apr 1, 1996·Circulation Research·J S ZhengM T Crow
Jul 4, 1996·European Journal of Pharmacology·J Z Sheng, T M Wong
Feb 1, 1997·The American Journal of Physiology·J Z ShengT M Wong
May 30, 1998·Journal of Molecular and Cellular Cardiology·X C YuT M Wong
Jul 11, 1998·Cardiovascular Research·T MiuraK Shimamoto
Oct 20, 1999·Journal of Molecular and Cellular Cardiology·X C YuT M Wong
May 9, 2000·The Journal of Biological Chemistry·C MoriscoJ Sadoshima
Jan 13, 2001·British Journal of Pharmacology·J D LuoX Chen
Aug 3, 2001·Journal of Cardiovascular Pharmacology·X C YuT M Wong
Nov 6, 2001·The Journal of Biological Chemistry·Tong ZhangJoan Heller Brown
Apr 27, 2002·Pflügers Archiv : European journal of physiology·Jian ShanTak-Ming Wong
Jul 3, 2003·Nature Reviews. Molecular Cell Biology·David H MacLennan, Evangelia G Kranias
Nov 18, 2003·The Journal of Physiology·Min WangJoshua R Berlin
Mar 6, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amjid A RiazHenrik Thorlacius
Sep 15, 2004·European Journal of Pharmacology·Guijun WangTak Ming Wong
Jan 11, 2005·Cardiovascular Research·Boyd R RorabaughDianne M Perez
Feb 28, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Carmen C SucharovMichael R Bristow
Nov 28, 2006·European Journal of Pharmacology·Dan ShanTak Ming Wong
Apr 3, 2007·Journal of Molecular and Cellular Cardiology·Norbert NagyDipak K Das
Citations
Mar 5, 2015·PloS One·Suping ZhangHongxin Wang
Dec 19, 2014·British Journal of Pharmacology·John P HeadrickJason N Peart
Oct 5, 2010·Critical Care Medicine·Quan-Yu ZhangJian-Ming Pei
Jul 22, 2018·Acta Pharmacologica Sinica·Bo YinMei-Li Lu
Mar 13, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Hemangi Rawal, Bhoomika M Patel
Apr 23, 2019·Medicine·Yuqin ZhangTianwei Zhan
Aug 24, 2010·Molecular and Cellular Biochemistry·Amardeep JaiswalSubir Kumar Maulik
Feb 24, 2009·European Journal of Pharmacology·Wen YinJian Ming Pei
Oct 2, 2009·Peptides·Richard J Bodnar