kappa-Opioid receptors control the metabolic response to a high-energy diet in mice.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Traci A CzyzykMichael A Statnick

Abstract

General opioid receptor antagonists reduce food intake and body weight in rodents, but the contributions of specific receptor subtypes are unknown. We examined whether genetic deletion of the kappa-opioid receptor (KOR) in mice alters metabolic physiology. KOR-knockout (KO) and wild-type (WT) mice were fed a high-energy diet (HED) for 16 wk. KO mice had 28% lower body weight and 45% lower fat mass when compared to WT mice fed an HED. No differences in caloric intake were found. An HED reduced energy expenditure in WT mice, but not in KO mice. KOR deficiency led to an attenuation of triglyceride synthesis in the liver. Malonyl CoA levels were also reduced in response to an HED, thereby promoting hepatic beta-oxidation. Glycemic control was also found to be improved in KO mice. These data suggest a key role for KORs in the central nervous system regulation of the metabolic adaptation to an HED, as we were unable to detect expression of KOR in liver, white adipose tissue, or skeletal muscle in WT mice. This study provides the first evidence that KORs play an essential physiological role in the control of hepatic lipid metabolism, and KOR activation is a permissive signal toward fat storage.-Czyzyk, T. A., Nogueiras, R., Lockwood, ...Continue Reading

References

May 28, 1985·European Journal of Pharmacology·J E MorleyG T Shearman
Nov 1, 1983·Peptides·J E Morley, A S Levine
Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·W N Shaw
Jun 14, 1993·Annals of the New York Academy of Sciences·J P Flatt
Jul 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·K YasudaG I Bell
Aug 1, 1996·The American Journal of Physiology·P A TataranniE Ravussin
May 29, 1998·Brain Research. Molecular Brain Research·S RoyH H Loh
Jul 27, 2000·American Journal of Physiology. Endocrinology and Metabolism·D ChienN B Ruderman
Sep 21, 2000·The Proceedings of the Nutrition Society·M E Lean
May 17, 2002·Progress in Neurobiology·Brigitte L Kieffer, Claire Gavériaux-Ruff
May 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael A StatnickMark L Heiman
Sep 23, 2003·Endocrinology·Neil B RudermanEdward W Kraegen
Feb 26, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Efi KokkotouEleftheria Maratos-Flier
May 20, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vladimir I CheferToni S Shippenberg
Feb 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elyssa B MargolisHoward L Fields
Apr 6, 2006·JAMA : the Journal of the American Medical Association·Cynthia L OgdenKatherine M Flegal
May 5, 2006·The Journal of Pharmacology and Experimental Therapeutics·Michael A AnsonoffJohn E Pintar
Nov 3, 2006·Nature Reviews. Drug Discovery·Dunstan Cooke, Steve Bloom
Feb 7, 2007·American Journal of Physiology. Endocrinology and Metabolism·G-Q ChangS F Leibowitz
Apr 26, 2007·Molecular Endocrinology·Amanda SainsburyHerbert Herzog
Dec 1, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Paul T PflugerMatthias H Tschöp
Jun 6, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Allison E SahrMichael A Statnick
Jul 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Paul T PflugerMatthias H Tschöp
Sep 19, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Walter WittmannChristoph Schwarzer

❮ Previous
Next ❯

Citations

May 1, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Russell S ThomasRussell D Wolfinger
May 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Traci A CzyzykRuben Nogueiras
Jan 24, 2013·PloS One·Sonia Perez-SieiraCarlos Dieguez
Jan 29, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ming-Qiang ZhengYiyun Huang
Mar 26, 2011·Journal of Opioid Management·David J MyselsMaria A Sullivan
Jan 26, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amparo Romero-PicóRubén Nogueiras
Oct 2, 2015·Pharmaceuticals·Joseph VamecqDries Dobbelaere
Jun 1, 2012·Obesity Facts·Ruben NogueirasCarlos Diéguez
May 10, 2018·Annals of the New York Academy of Sciences·Bridget A Matikainen-Ankney, Alexxai V Kravitz
Mar 2, 2019·Expert Opinion on Drug Discovery·Mar QuiñonesOmar Al-Massadi
Aug 29, 2017·Pediatric Research·Yanyan DaiXiaonan Li
Jul 12, 2019·Journal of Psychopharmacology·Jacobi I CunninghamMark Namchuk
Sep 8, 2019·Nature Communications·Patricia Seoane-CollazoMiguel López
Apr 9, 2020·Biology·Dmitry O IvanovRuslan A Nasyrov
Jul 9, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Monica ImbernonRuben Nogueiras
Aug 15, 2020·The American Journal of Psychiatry·Christoph U CorrellRené S Kahn
Sep 10, 2020·Science Signaling·Carlos GuijasGary Siuzdak
May 30, 2013·American Journal of Physiology. Endocrinology and Metabolism·Traci A CzyzykMichael A Statnick
Dec 2, 2020·The American Journal of Psychiatry·Robert W Buchanan
Feb 7, 2021·International Journal of Molecular Sciences·Patricia Seoane-CollazoMiguel López
Jun 7, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lola Rueda-RuzafaPablo Roman
Oct 11, 2011·Peptides·Richard J Bodnar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.