Kappa opioid receptors mediate an initial aversive component of paclitaxel-induced neuropathy

Psychopharmacology
Julie A MeadeM Imad Damaj

Abstract

Cancer patients receiving the antineoplastic drug paclitaxel report higher incidences and longer duration of treatment-resistant depression than patients receiving other classes of chemotherapeutics. Rodents treated with paclitaxel exhibit a suite of changes in affect-like behaviors. Further, paclitaxel causes chemotherapy-induced peripheral neuropathy (CIPN) in humans and rodents. Kappa opioid receptors (KOR) have a well-established role in depression and neuropathy. The contributions of KOR signaling to paclitaxel-induced aversive-like state and CIPN in rodents remain to be explored. We aimed to investigate whether dysregulation of the KOR/dynorphin system is associated with paclitaxel-mediated pain-like behavior and depression-like behavior. Cancer-free male C57BL/6J mice were treated with four injections of vehicle or paclitaxel (32 mg/kg cumulative). The effects of the selective KOR antagonist norbinaltorphimine (norBNI) on paclitaxel-induced sucrose preference deficits and mechanical hypersensitivity were measured. Prodynorphin mRNA and receptor-mediated G protein activation were measured at two time points following the last paclitaxel injection using quantitative real-time polymerase chain reaction and agonist-stimulate...Continue Reading

References

May 28, 1985·European Journal of Pharmacology·L E RobsonH W Kosterlitz
Nov 1, 1982·British Journal of Pharmacology·M G Gillan, H W Kosterlitz
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Jan 1, 1996·Anti-cancer Drugs·A SparreboomJ H Beijnen
Jan 10, 1997·The Journal of Biological Chemistry·A D BlakeT Reisine
Jun 9, 1997·Biochemical and Biophysical Research Communications·E BakogeorgouE Castanas
Jan 6, 2001·Journal of the American Society for Mass Spectrometry·A S Woods, M A Huestis
May 14, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mei XuCharles Chavkin
Jul 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Minoru NaritaTsutomu Suzuki
Jul 21, 2004·Journal of the National Cancer Institute. Monographs·Mary Jane Massie
Aug 25, 2004·Behavioural Brain Research·Stéphanie PothionCatherine Belzung
Dec 3, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Kurt F HauserToni S Shippenberg
Jan 18, 2006·Nature Neuroscience·Venetia ZachariouEric J Nestler
May 2, 2006·Physiology & Behavior·Yvonne M Ulrich-LaiJames P Herman
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yan-fang XiaGregory O Hjelmstad
Oct 19, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shannon Reagan-ShawNihal Ahmad
Oct 26, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael R BruchasCharles Chavkin
Jan 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Benjamin B LandCharles Chavkin
Jun 4, 2008·Cancer·Lisa M ThorntonBarbara L Andersen
Jun 6, 2009·Pharmacology & Therapeutics·William A CarlezonBruce M Cohen
Sep 29, 2009·Brain Research·Allison T Knoll, William A Carlezon
Sep 26, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Deirdre R PachmanCharles L Loprinzi
Dec 14, 2012·Nature·Jérémy BesnardAndrew L Hopkins
Apr 4, 2013·JAMA : the Journal of the American Medical Association·Ellen M Lavoie SmithUNKNOWN Alliance for Clinical Trials in Oncology
Jun 4, 2014·CA: a Cancer Journal for Clinicians·Carol E DeSantisAhmedin Jemal
Aug 31, 2014·Neuropharmacology·Ewelina RojewskaJoanna Mika
Dec 3, 2014·Frontiers in Pharmacology·Catherine M CahillChristopher J Evans
Dec 30, 2014·Frontiers in Psychiatry·Laurence LalannePierre-Eric Lutz

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Methods Mentioned

BETA
PCR
competition binding
saturation binding
transgenic

Software Mentioned

GraphPad Prism

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