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Kappa-receptor mechanisms in synaptosomal Ca uptake

General Pharmacology

Jan 1, 1989

T ToruM Hirobe

Abstract

1. Inhibition of Ca uptake by certain opioids was tested in synaptosomes of rat brain. The potency order was dynorphin A 1-13, a kappa-selective agonist greater than nalorphine greater than nalorphine epoxide greater than morphine. 2. The pA2 values (negative logarithms of dissociation ...read more

Mentioned in this Paper

Calcium Radioisotopes
Ethylketocyclazocine Methanesulfonate
Calcium
August Rats
Dinorphin A (1-13)
Peptide Fragments
Morphine Sulfate (2: 1), Pentahydrate
Dynorphin (1-17)
Receptors, Opioid, kappa
Cyclazocine
Paper Details
References
  • References18
  • Citations3
12

Kappa-receptor mechanisms in synaptosomal Ca uptake

General Pharmacology

Jan 1, 1989

T ToruM Hirobe

PMID: 2565850

DOI: 10.1016/0306-3623(89)90025-6

Abstract

1. Inhibition of Ca uptake by certain opioids was tested in synaptosomes of rat brain. The potency order was dynorphin A 1-13, a kappa-selective agonist greater than nalorphine greater than nalorphine epoxide greater than morphine. 2. The pA2 values (negative logarithms of dissociation ...read more

Mentioned in this Paper

Calcium Radioisotopes
Ethylketocyclazocine Methanesulfonate
Calcium
August Rats
Dinorphin A (1-13)
Peptide Fragments
Morphine Sulfate (2: 1), Pentahydrate
Dynorphin (1-17)
Receptors, Opioid, kappa
Cyclazocine

Related Papers

Paper Details
References
  • References18
  • Citations3
12
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