Karyology of a human colonic carcinoma (GW-39) serially xenografted in hamsters and in nude mice

Cancer Letters
D M GoldenbergL Smith

Abstract

A karyological analysis of the G-banded chromosomes of the serially transplantable GW-39 human colonic carcinoma was undertaken. GW-39 cells harvested from hamsters, nude (athymic) mice and cell cultures from 1972 to 1976 revealed a hypodiploid stemline of 45 human chromosomes, with a consistent loss of a 21-chromosome. No apparent alterations of the near-diploid stemline resulted during long-term xenogeneic propagation of this human cancer line.

References

Feb 15, 1975·International Journal of Cancer. Journal International Du Cancer·D M Goldenberg, R A Pavia
Oct 30, 1971·Lancet·M Seabright
Jan 1, 1970·Annual Review of Medicine·A A Sandberg, D K Hossfeld
Oct 11, 1972·Nature: New Biology·D M GoldenbergA P Vandevoorde
Aug 23, 1974·Nature·D M GoldenbergM C Tsao
Dec 1, 1970·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J Mark
Nov 1, 1966·Transplantation·D M GoldenbergK Elster
Sep 30, 1958·Annals of the New York Academy of Sciences·A LEVAN, J J BIESELE

Citations

Apr 17, 2012·Expert Opinion on Biological Therapy·D M Goldenberg
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y DeugnierJ Y Legall

Related Concepts

Metazoa
Chromosomes, Human
Malignant Tumor of Colon
Cricetus
Karyotype Determination Procedure
Mesocricetus
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation
Ploidies

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