Karyology of a human colonic carcinoma (GW-39) serially xenografted in hamsters and in nude mice

Cancer Letters
D M GoldenbergL Smith


A karyological analysis of the G-banded chromosomes of the serially transplantable GW-39 human colonic carcinoma was undertaken. GW-39 cells harvested from hamsters, nude (athymic) mice and cell cultures from 1972 to 1976 revealed a hypodiploid stemline of 45 human chromosomes, with a consistent loss of a 21-chromosome. No apparent alterations of the near-diploid stemline resulted during long-term xenogeneic propagation of this human cancer line.


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Related Concepts

Chromosomes, Human
Malignant Tumor of Colon
Karyotype Determination Procedure
Mice, Inbred BALB C
Mice, Nude
Neoplasm Transplantation

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