Karyomegalic interstitial nephritis: A new French case

Annales de pathologie
Jerome VerineDominique Droz

Abstract

Karyomegalic interstitial nephritis (KIN) is a rare and slowly progressive chronic interstitial nephritis (CIN) (28 cases reported), described for the first time by Mihatsch et al. in 1979. Here, we report on a 50-year-old woman who presented with asymptomatic renal failure and mild proteinuria without hematuria. Renal biopsy showed large tubulo-interstitial fibrosis and massively enlarged tubular epithelial cell nuclei, without viral inclusion. KIN is a rare CIN defined by a karyomegaly of tubular epithelial cell nuclei. Its pathogenesis remains obscure. Nevertheless, an exogenous factor is suspected, ochratoxin A particularly. The familial clustering of patients and the frequency of HLA-A9 and HLA-B35 haplotypes suggest the presence of a possible genetic susceptibility to this disorder.

References

Feb 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M SpoendlinG Thiel
Oct 29, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sunil BhandariJohn Horvath
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Michele RossiniAgnes B Fogo
May 9, 2006·Pathology, Research and Practice·Füsun BabaAndreas Friedl
Feb 17, 2007·Diagnostic Cytopathology·David PalmerKeneth Tompson

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Citations

Jul 25, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Aishwarya RavindranSanjeev Sethi

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