PMID: 9428614Jan 15, 1998Paper

Karyotype abnormalities and their clinical significance in blast crisis of chronic myeloid leukemia

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
M GriesshammerT M Fliedner

Abstract

We examined karyotypes and their prognostic significance in a series of 122 patients with chronic myeloid leukemia in blast crisis. Of 73 patients cytogenetically examined at the onset of blast crisis 63% had developed secondary cytogenetic abnormalities in addition to the Philadelphia chromosome. These newly emerging abnormalities included a double Philadelphia chromosome in 20 patients, a trisomy 8 in 17, and an isochromosome 17q in 11 patients. Development of such additional karyotypic abnormalities was significantly associated with a shorter median survival and less response to cytoreductive treatment and was significantly more common in nonlymphoid blast crisis than in the lymphoid-type blast crisis. Thus, assessment of karyotypes at the onset of chronic myeloid leukemia blast crisis appears to be of prognostic significance for both remission duration and survival.

Citations

Jan 22, 2004·Cancer Genetics and Cytogenetics·Juan Pablo Meza EspinozaJuan Ramón González García
May 30, 2001·Experimental Hematology·B N JahagirdarC M Verfaillie
Apr 9, 2005·Leukemia·J J W M JanssenG J Ossenkoppele
Dec 3, 2014·Hematology/oncology Clinics of North America·Andrew J Innes, Jane F Apperley
Apr 18, 2008·Leukemia Research·Sheeja T PullarkatJonathan W Said
Aug 19, 2000·Hematology/oncology Clinics of North America·R R MisraS Srivastava
Oct 6, 2020·Seminars in Diagnostic Pathology·Sonam PrakashWayne Tam
Apr 20, 2021·Oncotarget·Dorota KoczkodajMonika Podhorecka

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