Karyotype complexity and prognosis in acute myeloid leukemia

Blood Cancer Journal
Friedrich StölzelGerhard Ehninger

Abstract

A complex aberrant karyotype consisting of multiple unrelated cytogenetic abnormalities is associated with poor prognosis in patients with acute myeloid leukemia (AML). The European Leukemia Net classification and the UK Medical Research Council recommendation provide prognostic categories that differ in the definition of unbalanced aberrations as well as the number of single aberrations. The aim of this study on 3526 AML patients was to redefine and validate a cutoff for karyotype complexity in AML with regard to adverse prognosis. Our study demonstrated that (1) patients with a pure hyperdiploid karyotype have an adverse risk irrespective of the number of chromosomal gains, (2) patients with translocation t(9;11)(p21∼22;q23) have an intermediate risk independent of the number of additional aberrations, (3) patients with ⩾4 abnormalities have an adverse risk per se and (4) patients with three aberrations in the absence of abnormalities of strong influence (hyperdiploid karyotype, t(9;11)(p21∼22;q23), CBF-AML, unique adverse-risk aberrations) have borderline intermediate/adverse risk with a reduced overall survival compared with patients with a normal karyotype.

References

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Citations

Jan 26, 2017·Blood·Tilmann BochtlerUNKNOWN Study Alliance Leukemia Investigators
Aug 4, 2018·American Journal of Hematology·Yasmin AbazaGautam Borthakur
Feb 12, 2019·Current Treatment Options in Oncology·Yahya DaneshbodDaniel A Arber
Apr 20, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olga K WeinbergDaniel A Arber
Feb 6, 2018·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Jina BhattacharyyaDushyant Kumar
Jul 5, 2018·Journal of Oncology·Samra WaheedTahir S Shamsi
Sep 28, 2020·Journal of Cancer Research and Clinical Oncology·Andrés Cardona-Echeverry, Jeanette Prada-Arismendy
Nov 7, 2017·Clinical Lymphoma, Myeloma & Leukemia·Maliha KhanGautam Borthakur
Mar 23, 2021·Frontiers in Oncology·Chengliang YinYan Li
Jul 15, 2017·Experimental Hematology·Ciaran HassanChristopher E Mason
Oct 27, 2021·Journal of Research in Health Sciences·Masumeh Maleki BehzadHassan Rafieemehr

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