Karyotypic characteristics of borderline malignant tumors of the ovary: trisomy 12, trisomy 7, and r(1) as nonrandom features

Cancer Genetics and Cytogenetics
T PejovicS Heim

Abstract

Clonal karyotypic abnormalities were detected in five of 14 cytogenetically analyzed borderline malignant ovarian tumors of clinical stages I-II. One mucinous and one seropapillary tumor had trisomy 7 and r(1)(p36q42) as the sole chromosome abnormality, respectively. Trisomy 12 was found in the remaining three cases. It was the only change in one mucinous and one serous tumor, whereas the third, a seropapillary borderline tumor, had the karyotype 49,XX,+5,+8, +12. These findings, especially when collated with those of previous reports on ovarian borderline tumor cytogenetics, indicate that +12 is the most consistent chromosomal aberration in this group of neoplasms and that also +7 and r(1) are nonrandom features. From the karyotypic point of view, benign ovarian tumors and well-differentiated carcinomas are similar to borderline ovarian tumors, with the possible exception that the former have no tendency to form r(1). Highly malignant carcinomas, on the other hand, are typically much more complex. Chromosome-level changes therefore cannot account for the putative phenotypic passage through the most innocuous tumor stages as epithelial ovarian neoplasms go from benign to fully malignant.

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Citations

Jan 28, 2003·Cancer Genetics and Cytogenetics·Jie HuUrvashi Surti
Mar 25, 2000·Cancer Genetics and Cytogenetics·J WangP Eydoux
Mar 10, 2001·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·H. BlegenG. Auer
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R A HajekL A Jones
Feb 27, 2010·Journal of Translational Medicine·Francesca MicciSverre Heim
May 15, 2009·Genes, Chromosomes & Cancer·Mads ThomassenTorben A Kruse
Jun 2, 2006·Cancer Genetics and Cytogenetics·Lovisa OsterbergGyörgy Horvath

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