K(ATP) channel current increases in postinfarction remodeled cardiomyocytes

Pflügers Archiv : European journal of physiology
R SurberK Benndorf

Abstract

Adenosintriphosphate-sensitive potassium channels (K(ATP) channels) are an important linkage between the metabolic state of a cell and electrophysiological membrane properties. In this study, K(ATP) channels were studied in myocytes of normal and remodeled myocardium of the rat. Myocardial infarction was induced by ligature of the left anterior descending artery. Remodeled myocytes were obtained from the hypertrophied posterior left ventricular wall and interventricular septum 3 months after infarction. The current through K(ATP) channels was measured in whole-cell and inside-out patches by using the patch-clamp technique. After myocardial infarction, the heart weight/body weight ratio was doubled and the myocytes were hypertrophied yielding a cell capacitance of 266+/-16 pF compared to 122+/-12 pF in control cells. The amount of Kir6.2 protein was indistinguishable in corresponding regions of control and remodeled hearts. The ATP sensitivity of K(ATP) channels in remodeled cells was significantly lower than in control cells (half maximum block at 115 micromol/l ATP in remodeled and at 71 mumol/l ATP in control cells). The maximum I (KATP) density induced by metabolic inhibition was higher in small remodeled (176+/-15 pA/pF) th...Continue Reading

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Citations

Jan 8, 2013·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·John S CameronEsther Kang
Mar 28, 2007·Molecular and Cellular Biochemistry·Ronald B DriesenMarcel Borgers
Oct 17, 2008·Journal of Proteome Research·Caroline Cieniewski-BernardFlorence Pinet

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