K(ATP) channelopathies in the pancreas.

Pflügers Archiv : European journal of physiology
Maria S Remedi, Joseph C Koster

Abstract

Adenosine-triphosphate-sensitive potassium channels (KATP) are regulated by adenosine nucleotides, and, thereby, couple cellular metabolism with electrical activity in multiple tissues including the pancreatic beta-cell. The critical involvement of KATP in insulin secretion is confirmed by the demonstration that inactivating and activating mutations in KATP underlie persistent hyperinsulinemia and neonatal diabetes mellitus, respectively, in both animal models and humans. In addition, a common variant in KATP represents a risk factor in the etiology of type 2 diabetes. This review focuses on the mechanistic basis by which KATP mutations underlie insulin secretory disorders and the implications of these findings for successful clinical intervention.

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Citations

Oct 6, 2010·Reviews in Endocrine & Metabolic Disorders·Emma L EdghillSian Ellard
Jul 30, 2010·Science Translational Medicine·Andre Terzic, Carmen Perez-Terzic
Aug 19, 2011·Circulation. Arrhythmia and Electrophysiology·Andre TerzicTimothy M Olson
Mar 18, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Miaoying ZhangFeihong Luo
Oct 10, 2013·Biochemical and Biophysical Research Communications·Sun-Hyun ParkJu-Hong Jeon
Jul 21, 2016·Molecular Pharmacology·Myrian VelascoMarcia Hiriart
Jan 24, 2017·Pediatric Diabetes·Maria S RemediBess A Marshall
Sep 19, 2018·American Journal of Physiology. Endocrinology and Metabolism·Christopher H EmfingerMaria S Remedi
Jun 5, 2019·Physiological Reports·Christopher H EmfingerColin G Nichols
May 31, 2018·The Journal of General Physiology·Yajamana RamuZhe Lu
May 8, 2019·Scientific Reports·Zeenat A ShyrMaria S Remedi
Dec 9, 2010·Science Signaling·Michael SchiederChristian Wahl-Schott

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