K(ATP) channels contribute to the cardioprotection of preconditioning independent of anaesthetics in rabbit hearts

Journal of Molecular and Cellular Cardiology
Y MoritaS Sasayama

Abstract

The contribution of ATP sensitive potassium (K(ATP)) channels to the infarct-size limiting effect of preconditioning is considered to be anaesthetic-dependent in the rabbit heart. It has previously been reported that ischaemic preconditioning prevents ischaemia-induced reductions in activities of sarcolemmal adenylate cyclase (AC) and Na+, K(+)-ATPase. Anaesthetic dependency of the role of K(ATP) channels in the preservation of these enzyme activities, induced by ischaemic preconditioning, as well as that induced by activation of A1-adenosine receptors, was examined in rabbits anaesthetized with either pentobarbital or ketamine-xylazine and subjected to 20 min of regional ischaemia. Adenylate cyclase and Na+, K(+)-ATPase activities were lower in the ischaemic than in the non-ischaemic region of the hearts in control rabbits, but not in animals subjected to ischaemic preconditioning, or those pretreated with the A1-adenosine receptor agonist R(-)-N6-(2-phenylisopropyl) adenosine. The protective effects of both ischaemic preconditioning and A1-adenosine receptor activation were prevented by 6 mg/kg, but not 3 mg/kg, of the K(ATP) channel blocker, glibenclamide, in rabbits anaesthetized with pentobarbital, while these effects were...Continue Reading

Citations

May 14, 2011·Purinergic Signalling·Ana S F RibeiroMedardo Hernández
Mar 8, 2013·The Kaohsiung Journal of Medical Sciences·Ilker SengulJakob Vinten-Johansen
Mar 8, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Jeehee KimH Thomas Lee
Dec 22, 1999·The American Journal of Physiology·E J TanhehcoB R Lucchesi
Sep 20, 2000·American Journal of Physiology. Heart and Circulatory Physiology·E J TanhehcoB R Lucchesi
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Jun 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Christopher LotzThorsten M Smul

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