Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway

Journal of Natural Products
S S MizokamiW A Verri

Abstract

Kaurenoic acid [ent-kaur-16-en-19-oic acid (1)] is a diterpene present in several plants including Sphagneticola trilobata. The only documented evidence for its antinociceptive effect is that it inhibits the writhing response induced by acetic acid in mice. Therefore, the analgesic effect of 1 in different models of pain and its mechanisms in mice were investigated further. Intraperitoneal and oral treatment with 1 dose-dependently inhibited inflammatory nociception induced by acetic acid. Oral treatment with 1 also inhibited overt nociception-like behavior induced by phenyl-p-benzoquinone, complete Freund's adjuvant (CFA), and both phases of the formalin test. Compound 1 also inhibited acute carrageenin- and PGE(2)-induced and chronic CFA-induced inflammatory mechanical hyperalgesia. Mechanistically, 1 inhibited the production of the hyperalgesic cytokines TNF-α and IL-1β. Furthermore, the analgesic effect of 1 was inhibited by l-NAME, ODQ, KT5823, and glybenclamide treatment, demonstrating that such activity also depends on activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway, respectively. These results demonstrate that 1 exhibits an analgesic effect in a consistent manner and th...Continue Reading

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Citations

Jun 8, 2013·Journal of Natural Products·Sergio M BorghiWaldiceu A Verri
Sep 10, 2013·Life Sciences·Geovanna Nallely Quiñonez-BastidasVinicio Granados-Soto
Jun 21, 2014·Pharmacological Reports : PR·Larissa Staurengo-FerrariWaldiceu A Verri
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Apr 18, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tran Dinh ThangTian-Shung Wu
Feb 26, 2016·Neuropharmacology·Felipe A Pinho-RibeiroWaldiceu A Verri
Jun 16, 2015·Mediators of Inflammation·Milena Menegazzo MirandaWander Rogério Pavanelli
Sep 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Rejane Barbosa de OliveiraJairo Kenupp Bastos
Mar 12, 2013·Pharmacology, Biochemistry, and Behavior·Suelen A NavarroWaldiceu A Verri
Jun 12, 2016·Chemico-biological Interactions·Daniela T Longhi-BalbinotWaldiceu A Verri
Jun 27, 2014·Basic & Clinical Pharmacology & Toxicology·Kyung Hu KimSu Jin Kang
Aug 2, 2013·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D A C MagroW A Verri
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Aug 15, 2013·Natural Product Reports·James R Hanson
Mar 28, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rosa Mariana Montiel-RuizEver A Blé-González
Jan 29, 2017·Chemistry & Biodiversity·Xin-Hua MaYong-Hong Zhang
Jul 26, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Zineb El GabbasAbderrahman Chait
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Feb 9, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Jaqueline Lopes DamascenoCarlos Henrique Gomes Martins
Apr 2, 2013·Neuropharmacology·Ana C ZarpelonWaldiceu A Verri
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Danielle KianLucy Megumi Yamauchi

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