Kawasaki disease: abnormal initial echocardiogram is associated with resistance to IV Ig and development of coronary artery lesions

Pediatric Rheumatology Online Journal
Dima ChbeirUlrich Meinzer

Abstract

Kawasaki disease (KD) is an acute febrile systemic vasculitis that affects small and medium blood vessels. Intensified treatments for the most severely affected patients have been proposed recently, and the early identification of KD patients at high risk for coronary artery aneurysms (CAA) is crucial. However, the risk scoring systems developed in Japan have not been validated in European populations, and little data is available concerning the link between initial echocardiogram findings other than high z-scores and cardiac prognosis. In order to investigate whether the presence of any abnormalities, other than high z-scores in first echocardiogram, are associated with resistance to IV immunoglobulins and/or subsequent development of CAA, we retrospectively analyzed data from children diagnosed with KD between 2006 and 2016 at a tertiary Hospital in Paris, France. A total of 157 children were included. The initial echocardiogram was performed after a median of 7 days of fever and was abnormal in 48 cases (31%). The initial presence of any echocardiographic abnormality (coronary artery dilatation, CAA, pericardial effusion, perivascular brightness of the coronary arteries, left-ventricular dysfunction and mitral insufficiency)...Continue Reading

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Citations

Apr 20, 2019·Korean journal of pediatrics·Min Seob Song
Jan 21, 2021·Arquivos brasileiros de cardiologia·Diogo FaimAntónio Pires
Jun 5, 2020·American Heart Journal·Ryusuke AeErmias D Belay
Apr 1, 2021·Journal of the American Heart Association·Ryusuke AeErmias D Belay
Dec 23, 2021·Indian Journal of Pediatrics·Akanksha MahajanVirendra Kumar

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