Kawasaki disease and toxic shock syndrome--at last the etiology is clear?

Advances in Experimental Medicine and Biology
Nigel Curtis

Abstract

A decade after the superantigen hypothesis for KD was first suggested, it has still not been either proven or refuted conclusively. Although initial optimism for the hypothesis was quashed by a series of published papers apparently refuting the idea, in the last few years there have been a number of good studies providing evidence in support of the superantigen hypothesis. Whether this renewed enthusiasm is justified will hopefully become clear in the near future. Ultimately, accurate diagnosis, more targeted treatment, and preventative strategies depend on the unraveling of the immunopathogenesis of this disease.

Citations

Dec 12, 2007·Clinical and Experimental Immunology·P A BroganN Klein
Mar 1, 2008·Expert Opinion on Medical Diagnostics·Andrew C SteerJonathan R Carapetis
Jul 26, 2018·Frontiers in Pediatrics·Christian M HedrichToni Hospach
Jul 17, 2020·Frontiers in Cardiovascular Medicine·Mark Daniel Hicar
Apr 9, 2013·Journal of Paediatrics and Child Health·Deane YimDavid Burgner
Jun 13, 2012·Drugs·Andrew C SteerJonathan R Carapetis
May 2, 2007·Current Opinion in Infectious Diseases·Kousaku Matsubara, Takashi Fukaya
Apr 25, 2019·International Journal of Molecular Sciences·Michael E Lindquist, Mark D Hicar

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