"Keaping" a lid on lung cancer: the Keap1-Nrf2 pathway

Cell Cycle
Sarah A Best, Kate D Sutherland

Abstract

Lung cancer remains one of the world's deadliest cancers, with effective targeted treatment options available for only a small subset of patients. The rapid expansion of cancer genomics in recent years has provided insight into the genetic landscape of all major lung cancer subtypes and led to new discoveries on the heterogeneous biology underlying lung tumorigenesis. Interestingly, these studies have revealed a high frequency of alterations in the Kelch-like ECG-associated protein 1 (KEAP1)-Nuclear factor erythoid-2-related factor 2 (NRF2) stress response pathway, for which no targeted treatments are currently available. In this review, we describe the molecular mechanisms underlying NRF2 pathway activation in lung cancer cells, with a focus on in vivo functional studies in genetically engineered mouse models. Importantly, potential avenues and implications for therapeutic targeting of KEAP1-NRF2 pathway vulnerabilities for lung cancer patients will be highlighted.

References

Jun 21, 2001·American Journal of Respiratory Cell and Molecular Biology·D W BorthwickS H Randell
Oct 1, 2003·Nature Genetics·Nobunao WakabayashiMasayuki Yamamoto
Nov 17, 2005·Cancer Research·Erica L JacksonTyler Jacks
Mar 2, 2006·Molecular Cell·Balasundaram PadmanabhanMasayuki Yamamoto
Oct 6, 2006·PLoS Medicine·Anju SinghShyam Biswal
Aug 7, 2007·Nature·Hongbin JiKwok-Kin Wong
Dec 19, 2007·IUBMB Life·Marcia MunozMurray Norris
Sep 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tatsuhiro ShibataSetsuo Hirohashi
Mar 27, 2009·Trends in Biochemical Sciences·John D Hayes, Michael McMahon
May 23, 2009·Science·Matthew G Vander HeidenCraig B Thompson
Jun 13, 2009·American Journal of Respiratory Cell and Molecular Biology·David J BlakeShyam Biswal
Mar 7, 1927·The Journal of General Physiology·O WarburgE Negelein
Dec 8, 2009·The Journal of Pathology·Yoo Ri KimSug Hyung Lee
Jun 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Luisa M SolisIgnacio I Wistuba
Jul 3, 2010·Molecular Oncology·Kate D Sutherland, Anton Berns
Jul 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthew D WilkersonD Neil Hayes
Oct 14, 2010·Cancer Research·J Tyson McDonaldWilliam H McBride
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dongmei RenDonna D Zhang
Apr 8, 2011·Nature·Monte M WinslowTyler Jacks
Jul 14, 2012·Cancer Cell·Yoichiro MitsuishiHozumi Motohashi
Jul 20, 2012·Nature Reviews. Cancer·Michael B Sporn, Karen T Liby
Sep 11, 2012·Nature·UNKNOWN Cancer Genome Atlas Research Network
Mar 14, 2013·Molecular Oncology·Min-chul Kwon, Anton Berns
Aug 8, 2013·The Journal of Clinical Investigation·Anju SinghShyam Biswal
Oct 22, 2013·Genes & Development·Melba C Jaramillo, Donna D Zhang
Nov 1, 2013·The New England Journal of Medicine·Jagdeep Singh Gandhi
Jan 1, 2014·Molecular and Cellular Biology·Keiko TaguchiMasayuki Yamamoto
Mar 4, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kate D SutherlandAnton Berns

❮ Previous
Next ❯

Citations

Oct 30, 2019·Pediatric Hematology and Oncology·Dilara Fatma Akın-BalıTeoman Kankılıc
Nov 17, 2020·Frontiers in Oncology·Fen WangQing Zhou
Dec 12, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Jessica A HellyerHeather A Wakelee
Mar 3, 2021·Cellular Immunology·Jessica K Mandula, Paulo C Rodriguez
Jan 29, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ibiayi Dagogo-JackMari Mino-Kenudson
May 17, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Narek ShaverdianDaniel R Gomez
Apr 13, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joao V AlessiMark M Awad
Jul 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ritu MishraCarole R Mendelson
Jul 25, 2021·European Journal of Medicinal Chemistry·Vladimir SimovErin F DiMauro
Jun 30, 2021·Journal of the Chinese Medical Association : JCMA·Kung-Hao Liang, Mong-Lien Wang
Aug 28, 2021·Cells·Miriam Sánchez-OrtegaAntonio Garrido
Sep 26, 2021·Cell·Andrew G ManfordMichael Rape

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
xenograft

Related Concepts

Related Feeds

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

Related Papers

Advances in Cancer Research
Hanna M LeinonenAnna-Liisa Levonen
Current Opinion in Toxicology
David ChengAh-Ng Tony Kong
Free Radical Biology & Medicine
Yue GuoAh-Ng Tony Kong
Biochemical Society Transactions
Hanna M LeinonenAnna-Liisa Levonen
© 2022 Meta ULC. All rights reserved