Keepers at the final gates: regulatory complexes and gating of the proteasome channel

Cellular and Molecular Life Sciences : CMLS
M Bajorek, M Glickman

Abstract

The proteolytic active sites of the 26S proteasome are sequestered within the central chamber of its 20S catalytic core particle. Access to this chamber is through a narrow channel defined by the outer alpha subunits. Free proteasome 20S core particles are found in an autoinhibited state in which the N-termini of neighboring alpha subunits are anchored by an intricate lattice of interactions blocking access to the channel. Entry of substrates into proteasomes can be enhanced by attachment of activators or regulatory particles. An important part of this activation is channel gating; regulatory particles rearrange the blocking residues to form an open pore and promote substrate entry into the proteolytic chamber. Interestingly, some substrates can open the entrance themselves and thus facilitate their own destruction. In this review, we will discuss the mechanisms proposed for channel gating and the interactions required to maintain stable closed and open conformations.

Citations

Nov 26, 2010·Proceedings of the National Academy of Sciences of the United States of America·Stefan BohnStephan Nickell
Apr 2, 2011·The Journal of Biological Chemistry·Allen HendersonPhilip Coffino
May 15, 2010·Molecular & Cellular Proteomics : MCP·Friedrich FörsterWolfgang Baumeister
Mar 11, 2011·Molecular & Cellular Proteomics : MCP·Anca F Savulescu, Michael H Glickman
Jan 11, 2012·Antioxidants & Redox Signaling·Gustavo M SilvaMarilene Demasi
Oct 22, 2014·Biomolecules·Cordula Enenkel
Jul 24, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Madeline R ScottJames H Meador-Woodruff
Nov 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rui HuangLewis E Kay
Jan 22, 2010·Biopolymers·E JankowskaF Kasprzykowski
Jun 18, 2010·Amino Acids·S GrimmT Grune
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Michael P LathamLewis E Kay
Sep 10, 2015·Biomolecular Concepts·Frank ImkampEilika Weber-Ban
Feb 2, 2012·Journal of Biomolecular Structure & Dynamics·Bin XueVladimir N Uversky

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