Keeping a lid on nodal: transcriptional and translational repression of nodal signalling

Open Biology
Karuna Sampath, Elizabeth J Robertson

Abstract

Nodal is an evolutionarily conserved member of the transforming growth factor-β (TGF-β) superfamily of secreted signalling factors. Nodal factors are known to play key roles in embryonic development and asymmetry in a variety of organisms ranging from hydra and sea urchins to fish, mice and humans. In addition to embryonic patterning, Nodal signalling is required for maintenance of human embryonic stem cell pluripotency and mis-regulated Nodal signalling has been found associated with tumour metastases. Therefore, precise and timely regulation of this pathway is essential. Here, we discuss recent evidence from sea urchins, frogs, fish, mice and humans that show a role for transcriptional and translational repression of Nodal signalling during early development.

References

Nov 11, 1992·Nucleic Acids Research·K MarelloJ Sommerville
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M T MurrayW W Franke
Sep 21, 2000·Current Biology : CB·H I SirotkinW S Talbot
Feb 13, 2001·Biochemical and Biophysical Research Communications·S CemanS T Warren
Nov 26, 2002·Nature Cell Biology·Séverine BeckDaniel B Constam
Dec 25, 2002·Current Biology : CB·Benjamin FeldmanDerek L Stemple
Mar 13, 2003·Development Genes and Evolution·Jr-Kai YuLinda Z Holland
Aug 6, 2003·Journal of Molecular Biology·Claudio O GualerziCynthia L Pon
Sep 27, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Elizabeth J RobertsonElizabeth K Bikoff
May 8, 2004·Trends in Biochemical Sciences·Peter ten Dijke, Caroline S Hill
May 20, 2004·The Journal of Biological Chemistry·Sadia MunirChun Peng
Oct 2, 2004·Development·Matt KofronJanet Heasman
Jan 15, 2005·Current Biology : CB·J Ann Le GoodDaniel B Constam
Mar 8, 2005·Development·Clare Hudson, Hitoyoshi Yasuo
Sep 24, 2005·Journal of Cell Science·Ludovic VallierRoger A Pedersen
Dec 16, 2005·Nature·Aniket V GoreKaruna Sampath

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Citations

Jun 17, 2016·Open Biology·Arseniy R MorovKinya Yasui
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Rebecca D Burdine, Daniel T Grimes
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Iskra A SignoreMiguel L Concha
Jan 26, 2018·Journal of Cardiovascular Development and Disease·Axel SchweickertMartin Blum
Oct 24, 2017·Nucleic Acids Research·Andreas ZauckerKaruna Sampath
May 5, 2016·Development·Michael D Schneider
Aug 14, 2020·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Hiroshi Hamada
Mar 24, 2021·Briefings in Functional Genomics·Daniela M FigielAndrew C Nelson

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Methods Mentioned

BETA
CHIP-seq
RNA-seq
transfection

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