Keeping good friends close - The surface and secreted proteomes of a probiotic bacterium provide candidate proteins for intestinal attachment and communication with the host

Proteomics
Constance J Jeffery

Abstract

Bacteria use cell surface proteins and secreted proteins to interact with host tissues. Several dozen previously published proteomics studies have identified cell surface proteins for pathogens. In this issue, Celebioglu and Svensson (Proteomics 2017, 17, 1700019) use 2D gel electrophoresis and mass spectrometry to identify secreted and cell surface proteins of a commensual gut bacterium, Lactobacillus acidophilus NCFM. Some of the proteins are known to have functions in the cytoplasm, and their presence on the cell surface suggests they might be moonlighting proteins. In addition, comparisons of proteins used by pathogenic and probiotic species to interact with their hosts could lead to improved treatments of infections and chronic diseases that are associated with an imbalance of pathogenic and probiotic gut bacteria.

References

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May 26, 2004·Microbes and Infection·Celia R W CarneiroRicardo R Brentani
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Jun 26, 2015·PloS One·Vaishak Amblee, Constance J Jeffery
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May 18, 2016·International Journal of Biological Macromolecules·Dhaval K PatelDesh Deepak Singh
Apr 11, 2017·Proteomics·Hasan Ufuk Celebioglu, Birte Svensson

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Citations

May 17, 2018·PLoS Neglected Tropical Diseases·Meetali SinghUtpal Tatu

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