Keeping them quiet: BMPs maintain adult neural stem cell quiescence

Cell Stem Cell
Mantissa A Johnston, Daniel A Lim

Abstract

Neural stem cells (NSCs) in the adult dentate gyrus divide relatively infrequently, a trait that may prevent premature NSC depletion. In this issue of Cell Stem Cell, Mira et al. (2010) demonstrate that BMP signaling regulates the quiescence of dentate gyrus NSCs, restraining their proliferation to maintain long-term adult neurogenesis.

Citations

Mar 29, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Zorka BobchevaMaya Guncheva
Jan 23, 2020·Oncology Letters·Motofumi KoguchiTatsuya Abe

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