Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell development

European Journal of Immunology
John G Monroe, David Allman

Abstract

Trophic and instructive models have been invoked to explain how various cytokines influence the survival, proliferation and differentiation of lymphoid progenitors. There is evidence that IL-7 can act in either a trophic or an instructive manner during B and T cell development although its roles in B cell development in the fetus versus the adult mouse and in the mouse versus the human may vary. Here we outline the stages of B cell development and the conventional model of the role of IL-7 in the transitions from pro-B cells to pre-B cells and then to immature B cells. We also discuss the implications of recent data that have led to a new model for this process.

Citations

Oct 7, 2009·Immunology and Cell Biology·Mark N Cruickshank, Daniela Ulgiati
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Angela MalaspinaAnthony S Fauci
Nov 24, 2005·Seminars in Immunology·Craig D Milne, Christopher J Paige
Jun 5, 2018·Immunology and Cell Biology·Chie WatanabeEdward A Clark
May 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Terry J Fry, Crystal L Mackall
Sep 29, 2021·Journal of Cellular and Molecular Medicine·Mengwen YanJingang Zheng

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