Keeping up with the 'omics: non-equilibrium models of gene regulation

BMC Biology
David Pincus

Abstract

Non-equilibrium processes are vital features of biological systems. Despite this universally accepted fact, gene regulation is typically formalized into models that assume thermodynamic equilibrium. As experimental evidence expands the repertoire of non-equilibrium genome regulatory mechanisms, theoreticians are challenged to devise general approaches to accommodate and suggest functions for non-equilibrium processes. Ahsendorf et al. provide one such framework, which is discussed in the context of the growing complexity of eukaryotic gene regulation.

References

Jan 3, 2016·Chaos·Lifang HuangTianshou Zhou
Jan 18, 2017·Proceedings of the National Academy of Sciences of the United States of America·Stephen Ornes
Mar 10, 2016·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Westby G Fisher, Edward J Schloss

Citations

Oct 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J J Hopfield
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G K AckersM A Shea
Sep 28, 2004·Nature Structural & Molecular Biology·Scott C BlanchardJoseph D Puglisi
Sep 18, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bluma J LeschDavid C Page
Dec 6, 2014·BMC Biology·Tobias AhsendorfJeremy Gunawardena

Related Concepts

Saccharomyces cerevisiae
Genomics
Genome
Regulation of Biological Process

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