Kefir microbial composition is a deciding factor in the physiological impact of kefir in a mouse model of obesity.

The British Journal of Nutrition
Benjamin C T BourrieBenjamin P Willing

Abstract

Kefir consumption has been demonstrated to improve lipid and cholesterol metabolism; however, our previous study identified that benefits vary between different commercial and traditional kefir. Here, we investigate the ability of pitched culture kefir, that is, kefir produced by a small number of specific strains, to recapitulate health benefits of a traditional kefir, in a diet-induced obesity mouse model, and examine how microbial composition of kefir impacts these benefits. Eight-week-old female C57BL/6 mice were fed a high-fat diet (40 % energy from fat) supplemented with one of five kefir varieties (traditional, pitched, pitched with no Lactobacillus, pitched with no yeast and commercial control) at 2 ml in 20 g of food for 8 weeks prior to analysis of plasma and liver lipid profiles, and liver gene expression profiles related to lipid metabolism. Both traditional and pitched kefir lowered plasma cholesterol by about 35 % (P = 0·0005) and liver TAG by about 55 % (P = 0·0001) when compared with commercial kefir despite no difference in body weight. Furthermore, pitched kefir produced without either yeast or Lactobacillus did not lower cholesterol. The traditional and pitched kefir with the full complement of microbes were ...Continue Reading

References

Jul 26, 1990·The New England Journal of Medicine·E ReihnérB Angelin
Jul 7, 1988·The New England Journal of Medicine·S M Grundy
Dec 4, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J CrespoF Pons-Romero
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
May 25, 2005·The Journal of Dairy Research·Celso G VinderolaChantal Matar
Aug 30, 2005·Biochemical and Biophysical Research Communications·Mitsutaka InoueToshikatsu Okumura
Apr 14, 2006·The British Journal of Nutrition·Je-Ruei LiuChin-Wen Lin
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Apr 9, 2009·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Mariano MalaguarneraLucia Malaguarnera
Jun 15, 2010·Journal of Atherosclerosis and Thrombosis·Masashi UchidaMitsukazu Kitada
Nov 3, 2011·PloS One·Benjamin P WillingB Brett Finlay
Jun 2, 2012·World Journal of Gastroenterology : WJG·Yoshihisa TakahashiToshio Fukusato
Jun 19, 2013·Best Practice & Research. Clinical Gastroenterology·Amandine Everard, Patrice D Cani
Aug 15, 2013·Cancer Letters·Xiao-Yan DuanLiang Qiao
Sep 18, 2013·Nature Reviews. Gastroenterology & Hepatology·Rohit Loomba, Arun J Sanyal
Dec 18, 2013·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H-L ChenC-M Chen
Mar 27, 2015·Journal of Immunology Research·P CarasiM C Urdaci
Jul 8, 2015·Frontiers in Microbiology·Graciela L GarroteMartín Rumbo
Aug 11, 2015·Trends in Endocrinology and Metabolism : TEM·Michael RosenbaumRudolph L Leibel
Oct 16, 2015·Cellular and Molecular Life Sciences : CMLS·Philippe Gérard
May 21, 2016·Frontiers in Microbiology·Benjamin C T BourriePaul D Cotter
Dec 22, 2016·Current Opinion in Biotechnology·Maria L MarcoRobert Hutkins
Jan 24, 2017·Bioscience, Biotechnology, and Biochemistry·Jae-Woo ChoiHong-Yon Cho
Feb 9, 2017·Journal of Hepatology·Auvro R MridhaGeoffrey C Farrell
Oct 2, 2017·Cell Systems·Olga PonomarovaKiran Raosaheb Patil
Feb 19, 2019·The Journal of Nutritional Biochemistry·Mirian A Silva-CutiniTadeu U Andrade

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