KEGG: kyoto encyclopedia of genes and genomes

Nucleic Acids Research
M Kanehisa, S Goto

Abstract

KEGG (Kyoto Encyclopedia of Genes and Genomes) is a knowledge base for systematic analysis of gene functions, linking genomic information with higher order functional information. The genomic information is stored in the GENES database, which is a collection of gene catalogs for all the completely sequenced genomes and some partial genomes with up-to-date annotation of gene functions. The higher order functional information is stored in the PATHWAY database, which contains graphical representations of cellular processes, such as metabolism, membrane transport, signal transduction and cell cycle. The PATHWAY database is supplemented by a set of ortholog group tables for the information about conserved subpathways (pathway motifs), which are often encoded by positionally coupled genes on the chromosome and which are especially useful in predicting gene functions. A third database in KEGG is LIGAND for the information about chemical compounds, enzyme molecules and enzymatic reactions. KEGG provides Java graphics tools for browsing genome maps, comparing two genome maps and manipulating expression maps, as well as computational tools for sequence comparison, graph comparison and path computation. The KEGG databases are daily update...Continue Reading

References

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Citations

Sep 1, 1997·Trends in Genetics : TIG·M Kanehisa
Dec 16, 1997·Trends in Biochemical Sciences·M Kanehisa
Dec 10, 1998·Nucleic Acids Research·H OgataM Kanehisa
Dec 10, 1998·Nucleic Acids Research·A Bairoch, R Apweiler
Dec 11, 1999·Nucleic Acids Research·S GotoM Kanehisa

Related Concepts

Biochemical Pathway
Cellular Process
Genome
Genes
Gene Products, Protein
Gene Expression
Encyclopedias
Cell Cycle
Gene Function
Chromosomes

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