PMID: 9190201Feb 1, 1997Paper

Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton

Molecular Biology of the Cell
E Fuchs

Abstract

Since the time when I was a postdoctoral fellow under the supervision of Dr. Howard Green, then at the Massachusetts Institute of Technology, I have been interested in understanding the molecular mechanisms underlying growth, differentiation, and development in the mammalian ectoderm. The ectoderm gives rise to epidermal keratinocytes and to neurons, which are the only two cell types of the body that devote most of their protein-synthesizing machinery to developing an elaborate cytoskeletal architecture composed of 10-nm intermediate filaments (IFs). Our interest is in understanding the architecture of the cytoskeleton in keratinocytes and in neurons, and in elucidating how perturbations in this architecture can lead to degenerative diseases of the skin and the nervous system. I will concentrate on the intermediate filament network of the skin and its associated genetic disorders, since this has been a long-standing interest of my laboratory at the University of Chicago.

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·E FuchsP A Coulombe
Jan 1, 1991·Cytogenetics and Cell Genetics·M RosenbergT B Shows
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R VassarE Fuchs
Oct 1, 1983·The Journal of Cell Biology·U AebiT T Sun
May 1, 1994·The Journal of Cell Biology·E Fuchs
Nov 1, 1994·Genes & Development·E L RuggR A Eady

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Citations

Apr 12, 2008·Purinergic Signalling·Kayoko FujishitaKazuhide Inoue
Oct 23, 1997·Current Opinion in Cell Biology·R E Burgeson, A M Christiano
Sep 10, 1999·Postepy biochemii·M Staszczak, E Zdunek
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Jun 12, 2002·Molecular Biology of the Cell·Diana M ToivolaM Bishr Omary
Oct 17, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Michael P ShakarjianJeffrey D Laskin
Jul 26, 2003·Journal of Biomedical Optics·Robert J Werrlein, Janna S Madren-Whalley
Mar 14, 2000·Molecular and Cellular Biology·S SinhaE Fuchs
Oct 5, 2001·Molecular and Cellular Biology·J M ParamioJ L Jorcano
Jan 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·R SpanbroekA J Habenicht
Dec 5, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Fabian RunkelMartin Hrabé de Angelis
Jul 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·D M ToivolaJ E Eriksson
Feb 14, 2002·The Journal of Investigative Dermatology·Akemi Ishida-YamamotoHajime Iizuka
Nov 25, 2003·The British Journal of Dermatology·R H RiceP M Elias
May 21, 2008·International Journal of Cosmetic Science·M-C MéchinM Simon
Jul 11, 2006·Journal of Molecular Biology·Harald BärHarald Herrmann
Oct 29, 1998·Biochemical and Biophysical Research Communications·J Falk-MarzillierV Quaranta
Jun 9, 2000·Clinical and Experimental Dermatology·P B Cserhalmi-FriedmanA M Christiano
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jesus M Paramio, José L Jorcano
Dec 18, 1998·The Journal of Biological Chemistry·J FradetteP A Coulombe
Nov 13, 2019·Journal of Aging and Physical Activity·Johanna PoppLisa Marie Warner
Oct 3, 2001·The Journal of Biological Chemistry·G M XuM A Arnaout
Jun 29, 2001·Journal of Applied Toxicology : JAT·R J Werrlein, J S Madren-Whalley
Apr 26, 2002·Cell Death and Differentiation·R G Oshima
Jun 14, 2000·Archives of Biochemistry and Biophysics·J SnáselI Pichová

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