Kelch Mutations in Plasmodium falciparum Protein K13 Do Not Modulate Dormancy after Artemisinin Exposure and Sorbitol Selection In Vitro.

Antimicrobial Agents and Chemotherapy
Kimberly F BreglioThomas E Wellems

Abstract

Some Kelch mutations of the Plasmodium falciparum K13 protein confer increased survival to dihydroartemisinin (DHA)-treated ring-stage parasites. Here, we asked if K13 mutations affect a dormancy phenotype allowing parasites to survive DHA exposure and then sorbitol selection. Although recrudescence from dormancy differed between two distinct parasite lines, it was similar for isogenic lines carrying single-site substitutions in K13. Therefore, K13 mutations do not alter the DHA-sorbitol combined dormancy phenotype; rather, traits from other loci likely determine this phenotype.

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Citations

Jun 7, 2019·Tropical Medicine and Infectious Disease·Laura E Heller, Paul D Roepe
Dec 7, 2019·Proceedings of the National Academy of Sciences of the United States of America·Alex RosenbergL David Sibley

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