Keloid risk in patients with atopic dermatitis: a nationwide retrospective cohort study in Taiwan

BMJ Open
Ying-Yi LuChieh-Hsin Wu

Abstract

The pathogenesis of keloid is largely unknown. Because keloid and atopic dermatitis have overlapping pathophysiological mechanisms, we aimed to evaluate keloid risk in patients with atopic dermatitis. Population-based retrospective cohort study. The Taiwan National Health Insurance Research Database was used to analyse data for people who had been diagnosed with atopic dermatitis. We identified 8371 patients with newly diagnosed atopic dermatitis during 1996-2010. An additional 33 484 controls without atopic dermatitis were randomly identified and frequency matched at a one-to-four ratio. The association between atopic dermatitis and keloid risk was estimated using Cox proportional hazard regression models. After adjustment for covariates, the atopic dermatitis patients have a 3.19-fold greater risk of developing keloid compared with the non-atopic dermatitis group (3.19vs1.07 per 1000 person-years, respectively). During the study period, 163 patients with atopic dermatitis and 532 patients without atopic dermatitis developed keloid. Notably, keloid risk increased with severity of atopic dermatitis, particularly in patients with moderate to severe atopic dermatitis. Our results indicate that patients with atopic dermatitis had ...Continue Reading

References

Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·F S Dhabhar, B S McEwen
Aug 21, 2001·The Journal of Investigative Dermatology·M AltemusR D Granstein
Sep 6, 2003·The Journal of Surgical Research·Wei ChenZhiyong Sheng
Feb 13, 2004·World Journal of Surgery·John F SheridanPhillip T Marucha
Aug 12, 2004·The Journal of Investigative Dermatology·Ina M HadshiewRalf Paus
Jan 25, 2006·The Journal of Experimental Medicine·Yong-Jun Liu
Sep 7, 2006·Current Opinion in Allergy and Clinical Immunology·Hideo Hashizume, Masahiro Takigawa
Mar 7, 2007·Acta Dermato-venereologica·Gil YosipovitchLim Fong Seng
Jul 20, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Ricarda A JoachimPetra C Arck
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·Liana Manolache, Vasile Benea
Sep 25, 2007·Brain, Behavior, and Immunity·Stephanie L BowersRandy J Nelson
Nov 23, 2007·Annales de dermatologie et de vénéréologie·L MiseryUNKNOWN Pour le Groupe Psychodermatologie
Apr 15, 2008·Medical Hypotheses·Satoshi AkaishiHiko Hyakusoku
Jan 17, 2009·Clinical Biochemistry·Aya MatsusueYoshihiro Miyake
Mar 12, 2009·Drugs·Giampaolo RicciMassimo Masi
May 7, 2010·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Eun Byoul LeeKyu-Earn Kim
Apr 12, 2011·Current Pharmaceutical Design·Sarah M Richey, Andrew D Krystal
Oct 14, 2011·The New England Journal of Medicine·Alan D IrvineDonald Y M Leung
Nov 22, 2011·Acta Dermato-venereologica·Andrea L SuárezMartin Steinhoff
Mar 13, 2012·Journal of Psychosomatic Research·Fabianne FurtadoLydia Masako Ferreira
May 15, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ching-Shan ShyuLin-Shien Fu
Jun 12, 2012·The Journal of Clinical Investigation·Miho MasuokaKenji Izuhara
Jun 23, 2012·BMC Dermatology·Anne-Cécile Zoung-Kanyi BissekWalinjom F T Muna
Jul 13, 2012·Journal of Cutaneous Medicine and Surgery·Richard YuYouwen Zhou
Feb 5, 2013·Archives of Dermatological Research·Melissa SerravalloNeil I Brody
Dec 20, 2013·Postȩpy dermatologii i alergologii·Ewa Teresiak-MikołajczakWojciech Silny
Oct 1, 2012·Advances in Wound Care·Martha H VieraBrian Berman
Mar 19, 2014·The Journal of Dermatology·Mitsutoshi Tominaga, Kenji Takamori
Aug 22, 2014·Deutsches Ärzteblatt International·Thomas WerfelAlexander Kapp
Sep 10, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jianyu HanLijun Hao
Sep 17, 2014·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lung-Chi WuChih-Chiang Chen
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Mei MingYu-Ying He
Feb 25, 2015·Clinical, Cosmetic and Investigational Dermatology·Bernardo HochmanLydia Masako Ferreira
Dec 18, 2015·Indian Journal of Dermatology·Enes HajdarbegovicTamar Nijsten

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Citations

Nov 21, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·A DiazE Guttman-Yassky
Dec 18, 2020·Frontiers in Immunology·Jianni WuEmma Guttman-Yassky
Jan 9, 2021·BMC Musculoskeletal Disorders·Chun-Ching LuChieh-Hsin Wu
Feb 6, 2021·Postgraduate Medical Journal·Ying-Yi LuChieh-Hsin Wu
May 2, 2021·Scientific Reports·Ying-Yi LuChih-Hung Lee
Jun 16, 2021·Archives of Dermatological Research·Giuseppe IngrasciGil Yosipovitch
Jun 29, 2021·JAAD Case Reports·Audrey Jia Shin Wong, Eingun James Song
Sep 15, 2021·Acta Dermato-venereologica·Ahmed A HawashGil Yosipovitch

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