PMID: 7544699May 26, 1995Paper

Keratan sulphate is a marker of differentiation of ramified microglia

Brain Research. Developmental Brain Research
A BertolottoA Riccio

Abstract

Recently we reported that the keratan sulphate epitope recognised by the monoclonal antibody 5D4 is expressed by a population of ramified microglia in adult rats. As ramified microglia is believed to differentiate from ameboid microglia during postnatal development, we studied the rat brain from birth to 90 postnatal days of life with the monoclonal antibody 5D4. Contrary to all the other microglia markers until now described, keratan sulphate is not expressed by ameboid microglia and by macrophages but appears on the surface of microglia only when the cells are differentiated and show ramified processes. The keratan sulphate positive cells become evident at different times in different central nervous system areas; the first were localised in the pyriform cortex and brainstem from the end of the second postnatal week. These observations suggest that keratan sulphate expression on microglia cells is induced by differentiation and by a resting functional state. Moreover the 5D4 monoclonal antibody showed a strong diffuse positive staining of some cortical, thalamic and white matter areas during the first two postnatal weeks. This staining was transient and it does not seem biologically correlated with the expression of the kerat...Continue Reading

References

Sep 1, 1990·Brain Pathology·M B Graeber, W J Streit
Nov 15, 1991·The Journal of Comparative Neurology·J Gehrmann, G W Kreutzberg
Jun 1, 1991·Journal of Neuroscience Research·A BertolottoD Schiffer
Dec 1, 1990·Journal of the Neurological Sciences·A BertolottoD Schiffer
Oct 1, 1987·The Journal of Experimental Medicine·V H Perry, S Gordon
Jun 1, 1988·Trends in Neurosciences·V H Perry, S Gordon
Jul 1, 1984·The Journal of Comparative Neurology·T KitamuraS Fujita
Oct 15, 1993·Brain Research. Developmental Brain Research·E E Geisert, D J Bidanset
Jan 1, 1993·Glia·R B BanatiG W Kreutzberg
Apr 1, 1993·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A BertolottoD Schiffer

❮ Previous
Next ❯

Citations

Sep 6, 2003·Journal of Immunological Methods·Karin LundinMats A A Persson
Sep 30, 1998·The European Journal of Neuroscience·J G SchulzU Dirnagl
Sep 2, 2003·Journal of Neuroscience Research·Cheng Zhang, Mark O M Tso
Apr 13, 2017·Glycoconjugate Journal·Kazuchika Nishitsuji, Kenji Uchimura
Jul 19, 1996·The Journal of Biological Chemistry·B LindahlU Lindahl

❮ Previous
Next ❯

Related Concepts

Related Feeds