Keratin 17 identifies the most lethal molecular subtype of pancreatic cancer.

Scientific Reports
Lucia Roa-PeñaLuisa F Escobar-Hoyos

Abstract

Although the overall five-year survival of patients with pancreatic ductal adenocarcinoma (PDAC) is dismal, there are survival differences between cases with clinically and pathologically indistinguishable characteristics, suggesting that there are uncharacterized properties that drive tumor progression. Recent mRNA sequencing studies reported gene-expression signatures that define PDAC molecular subtypes that correlate with differences in survival. We previously identified Keratin 17 (K17) as a negative prognostic biomarker in other cancer types. Here, we set out to determine if K17 is as accurate as molecular subtyping of PDAC to identify patients with the shortest survival. K17 mRNA was analyzed in two independent PDAC cohorts for discovery (n = 124) and validation (n = 145). Immunohistochemical localization and scoring of K17 immunohistochemistry (IHC) was performed in a third independent cohort (n = 74). Kaplan-Meier and Cox proportional-hazard regression models were analyzed to determine cancer specific survival differences in low vs. high mRNA K17 expressing cases. We established that K17 expression in PDACs defines the most aggressive form of the disease. By using Cox proportional hazard ratio, we found that increased e...Continue Reading

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Citations

Mar 12, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Grainne M O'KaneSandra E Fischer
Oct 28, 2019·Human Pathology·Ji Dong K BaiKenneth R Shroyer
Jun 20, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Kester HayeKenneth R Shroyer
Jun 3, 2021·Cancer Cytopathology·Lucia Roa-PeñaKenneth R Shroyer
Jun 5, 2021·American Journal of Clinical Pathology·Sruthi BabuKenneth R Shroyer
Jun 13, 2021·Genes & Development·Gregory L BeattyDiane M Simeone
Jul 6, 2021·Signal Transduction and Targeted Therapy·Shun WangQiong-Zhu Dong

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Methods Mentioned

BETA
RNA-Seq
surgical
biopsy

Software Mentioned

MOFFITT
Graph Pad
Graph pad prism
SAS

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