Keratin 6, 16 and 17-Critical Barrier Alarmin Molecules in Skin Wounds and Psoriasis

Cells
Xiaowei ZhangLing-Juan Zhang

Abstract

Located at the skin surface, keratinocytes (KCs) are constantly exposed to external stimuli and are the first responders to invading pathogens and injury. Upon skin injury, activated KCs secrete an array of alarmin molecules, providing a rapid and specific innate immune response against danger signals. However, dysregulation of the innate immune response of KCs may lead to uncontrolled inflammation and psoriasis pathogenesis. Keratins (KRT) are the major structural intermediate filament proteins in KCs and are expressed in a highly specific pattern at different differentiation stages of KCs. While KRT14-KRT5 is restricted to basal proliferative KCs, and KRT10-KRT1 is restricted to suprabasal differentiated KCs in normal skin epidermis, the wound proximal KCs downregulate KRT10-K1 and upregulate KRT16/KRT17-KRT6 upon skin injury. Recent studies have recognized KRT6/16/17 as key early barrier alarmins and upregulation of these keratins alters proliferation, cell adhesion, migration and inflammatory features of KCs, contributing to hyperproliferation and innate immune activation of KCs in response to an epidermal barrier breach, followed by the autoimmune activation of T cells that drives psoriasis. Here, we have reviewed how kera...Continue Reading

References

Jan 1, 1987·Current Topics in Developmental Biology·E FuchsM Rosenberg
Jul 1, 1983·The Journal of Investigative Dermatology·T T SunJ Woodcock-Mitchell
Jan 1, 1983·Current Problems in Dermatology·T T SunJ Woodcock-Mitchell
Sep 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·P A CoulombeK Takahashi
Mar 19, 1999·Molecular and Cellular Biology·J M ParamioJ L Jorcano
Sep 1, 1999·Clinical and Experimental Immunology·A S GudmundsdottirI Jonsdottir
Sep 6, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·J M MommersP C van De Kerkhof
Feb 17, 2001·The Journal of Investigative Dermatology·M KomineM Blumenberg
May 2, 2001·Nature Cell Biology·A JacintoP Martin
Aug 28, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·G WeissH Trau
Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Stacy MazzalupoPierre A Coulombe
Mar 5, 2003·Cellular and Molecular Life Sciences : CMLS·J KirfelJ Reichelt
Oct 22, 2003·The Journal of Cell Biology·Pauline Wong, Pierre A Coulombe
Apr 17, 2004·European Journal of Cell Biology·Michael HesseThomas M Magin
Oct 16, 2004·The Journal of Investigative Dermatology·Peter J Koch, Dennis R Roop
Dec 25, 2004·Differentiation; Research in Biological Diversity·Michael A RogersJürgen Schweizer
Feb 1, 2005·European Journal of Cell Biology·Pierre A CoulombePauline Wong
Feb 1, 2005·European Journal of Cell Biology·Julia ReicheltThomas M Magin
Mar 30, 2005·Journal of Dermatological Science·Z ShenY-F Liu
Jul 7, 2005·The Journal of Experimental Medicine·Frank O NestleMichel Gilliet
Jul 13, 2006·The Journal of Cell Biology·Jürgen SchweizerMathew W Wright
Oct 31, 2006·The Journal of Investigative Dermatology. Symposium Proceedings·Brian J NickoloffMark W Lingen
Apr 13, 2007·The Journal of Investigative Dermatology·Hideki WatanabeLars E French
Jun 30, 2007·Current Biology : CB·Laurence FeldmeyerHans-Dietmar Beer
Jul 31, 2007·Lancet·Christopher Em Griffiths, Jonathan Nwn Barker
Jan 17, 2008·Critical Reviews in Eukaryotic Gene Expression·Priyadharsini NagarajanSatrajit Sinha
Apr 9, 2008·Dermatologic Therapy·Julia Tzu, Francisco Kerdel
Aug 8, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Behnam Naderi KalaliMarkus Ollert
Aug 23, 2008·Journal of the American Academy of Dermatology·Carlos A CharlesRobert S Kirsner
Jul 10, 2009·The Journal of Clinical Investigation·Harald HerrmannUeli Aebi
Nov 26, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sancy A LeachmanRoger L Kaspar
Mar 30, 2010·Immunity·Amanda L Blasius, Bruce Beutler
Jul 29, 2011·The Journal of Investigative Dermatology·Xiaowei ShiGang Wang
Sep 9, 2011·Molecular Biology of the Cell·Hunain AlamMilind M Vaidya

❮ Previous
Next ❯

Citations

Apr 26, 2020·Contact Dermatitis·Klaziena PolitiekMarie L A Schuttelaar
Feb 23, 2020·International Journal of Molecular Sciences·Makoto Sugaya
Nov 3, 2020·Experimental Dermatology·Ayaka YoshidaIkuko Yano
Dec 7, 2020·Toxicology Letters·Francesca FerraraGiuseppe Valacchi
Jan 13, 2021·Scientific Reports·Elisabeth HofmannPetra Kotzbeck
Nov 25, 2020·Journal of Personalized Medicine·Christopher R Heier Cooperative International Neuromuscular Research Group Cinrg Investigators
Jan 25, 2021·The Journal of Allergy and Clinical Immunology·Matthew T PatrickLam C Tsoi
Apr 4, 2021·Biomolecules·Fabian GendrischUte Wölfle
Mar 28, 2021·The Journal of Investigative Dermatology·Micah BelzbergShawn G Kwatra
Apr 13, 2021·Frontiers in Bioengineering and Biotechnology·Eleonora MauriziGraziella Pellegrini
May 20, 2020·Current Biology : CB·Kathleen J GreenScott A Nichols
Jun 3, 2021·International Journal of Molecular Sciences·Magdalena Jedrzejczak-SilickaRafał Rakoczy
Jun 4, 2021·Experimental and Molecular Pathology·Laurie B JosephJeffrey D Laskin
Jul 3, 2021·International Journal of Molecular Sciences·Erin M O'ShaughnessyPatricia E Martin
Jul 8, 2021·Seminars in Cell & Developmental Biology·Yiting LinGang Wang
Jul 13, 2021·Translational Vision Science & Technology·Shuo JiaJonathan Cheuk-Hung Chan
Aug 28, 2021·International Journal of Molecular Sciences·Raymond L KongerMatthew J Turner
Sep 12, 2021·Matrix Biology : Journal of the International Society for Matrix Biology·Florian PetersChristoph Becker-Pauly
Oct 8, 2021·Nano Letters·Ruifang HanChung Hang Jonathan Choi

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear translocation
transgenic
antisense oligonucleotides

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Biophysics of Adhesion

Alterations in cell adhesion can disrupt important cellular processes and lead to a variety of diseases, including cancer and arthritis. It is also essential for infectious organisms, such as bacteria or viruses, to cause diseases. Understanding the biophysics of cell adhesion can help understand these diseases. Discover the latest research on the biophysics of adhesion here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Related Papers

Dermatology : International Journal for Clinical and Investigative Dermatology
J M MommersP C van de Kerkhof
Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology
H HogenEschJ P Sundberg
Histology and Histopathology
Enrique ArciniegasMarina Chopite
The International Journal of Biochemistry & Cell Biology
Giulia Tonel, Curdin Conrad
© 2021 Meta ULC. All rights reserved