PMID: 111242Jun 1, 1979

Keratin cytoskeletons in epithelial cells of internal organs

Proceedings of the National Academy of Sciences of the United States of America
T T SunH Green

Abstract

An antiserum against human epidermal keratins was used to detect keratins in frozen sections of various rabbit and human tissues by indirect immunofluorescence. Strong staining was observed in all stratified squamous epithelia (epidermis, cornea, conjunctiva, tongue, esophagus, vagina, and anus), in epidermal appendages (hair follicle, sebaceous gland, ductal and myoepithelial cells of sweat glands), as well as in Hassall's corpuscles of the thymus, indicating that all contain abundant keratins. No staining by the antiserum was observed in fibroblasts, muscle of any type, cartilage, blood vessel, nerve tissue, iris or lens epithelium, or the glomerular or tubular cells of the kidney. In contrast, the antiserum stained the cells of most epithelia of the intestinal tract, urinary tract (urethra, bladder, ureter, collecting ducts of kidney), female genital tract (cervix, cervical glands, uterus, and oviduct), and respiratory tract (trachea and bronchi). Epithelial cells of the fine ductal system in the pancreas and submaxillary gland also stained well. When primary cultures of epithelial cells derived from bladder, intestine, kidney, and trachea were grown on glass coverslips and stained with anti-keratin, fiber networks similar t...Continue Reading

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Related Concepts

Endocervical Gland Structure
Immunofluorescence Assay
Cervical Glands
Animal Oviduct
Entire Hair Follicle
Urethra
Specimen Type - Fibroblasts
Epithelium of Lens
Respiratory Tract Structure
Neoplasm of Uncertain or Unknown Behavior of Bladder

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