PMID: 9181365May 1, 1997Paper

Keratin expression in anal carcinoma: an immunohistochemical study

Histopathology
G T WilliamsI M Leigh

Abstract

The keratin expression of 40 frozen tissue specimens of anal carcinoma was investigated using a panel of 17 monoclonal antibodies to 14 individual keratins. The tumours were divided into three histological subgroups showing pure squamous, squamous and basaloid, or squamous and glandular differentiation. A further assessment of the tumour grade was made. The overall profile was of expression of keratins 4, 13, 17, 18 and 19 across the majority of the tumours, with the minority expressing keratins 1 and 10, and keratin 7. Dedifferentiation was associated with loss of expression of keratinocyte keratins, particularly the cornification markers keratin 1 and 10, and K6 and 16 associated with keratinocyte hyperproliferation and differentiation. This correlated with acquisition of the simple epithelial keratins 7 and 8. Compared with the tumours as a whole, well differentiated squamous tumours (the most easily identifiable histological group) showed consistent positivity for keratins 6 and 16, expressed suprabasally, while simple keratins 18 and 19 were also found. Independent of grade, mixed tumours showed more widespread positivity for simple epithelial keratins 7, 8 and 18 and loss of expression of cornification keratins 1 and 10 a...Continue Reading

Citations

Jan 27, 2007·The American Journal of Surgical Pathology·Scott R Owens, Joel K Greenson
Jun 17, 2008·Annales de pathologie·Denis ChatelainJean-François Fléjou
Jun 11, 2008·Cytopathology : Official Journal of the British Society for Clinical Cytology·M R GhignaM Fabre
Jan 31, 2003·Pathology·Claus Fenger
May 16, 2015·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eric J YangMichael Herfs
Dec 16, 2016·The Journal of Pathology·Michael HerfsPhilippe Delvenne
Dec 18, 2013·The American Journal of Surgical Pathology·Rosalynn M NazarianLawrence R Zukerberg
Nov 6, 2004·Breast Cancer Research and Treatment·Eileen RakovitchLawrence Paszat

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