Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα

The Journal of Investigative Dermatology
Fanny LoschkeThomas M Magin

Abstract

Expression and interaction of desmosomal components and keratins provide stable cell cohesion and protect the epidermis against various types of stress. The differentiation-specific isotype composition of the keratin cytoskeleton and desmosomes is regarded as a major determinant of adhesive strength. In support, wound healing is characterized by a transient decrease in desmosomal adhesion accompanied by increased expression of keratins K6/K16/K17 at the expense of K1/K10. The significance of altered keratin expression for desmosomal composition and adhesion remains incompletely understood at a mechanistic and functional level. Here, we investigated the respective contribution of K5/K14 or K6/K17 to desmosome adhesion, on their stable re-expression in keratinocytes lacking all keratins. This revealed that K5/K14 filaments support stable desmosomes, whereas "wound healing" keratins K6/K17 induce elevated protein kinase C alpha-mediated desmosome disassembly and subsequent destabilization of epithelial sheets. Moreover, our data suggest that K5/K14 sequester protein kinase C alpha in the cytoplasm, whereas K6/K17 or the absence of all keratins enables protein kinase C alpha translocation to the plasma membrane and induction of des...Continue Reading

Citations

Feb 20, 2020·Molecular Biology of the Cell·Richard A MarianiGregory F Weber
Aug 12, 2016·PloS One·Rumana KhanomKei Sakamoto
Jun 28, 2019·Cellular and Molecular Life Sciences : CMLS·Marcin MochRudolf E Leube
Jun 3, 2017·Scientific Reports·Martin FischerKurt Engeland
Oct 28, 2019·Essays in Biochemistry·Sungjun Yoon, Rudolf E Leube
Mar 4, 2020·Journal of Cell Science·Lisa MüllerMechthild Hatzfeld
Apr 21, 2019·Cells·Tim Hohmann, Faramarz Dehghani
May 2, 2018·Cellular and Molecular Bioengineering·Hoda ZarkoobE A Sander
Jun 26, 2017·Archives of Dermatological Research·Tina ZupancicMirjana Liovic
Sep 30, 2017·Frontiers in Cell and Developmental Biology·Rucha Sanghvi-Shah, Gregory F Weber
Jan 9, 2020·Cellular and Molecular Life Sciences : CMLS·Susanne KarschAndreas Janshoff
Apr 5, 2018·Frontiers in Immunology·Franziska VielmuthJens Waschke
Sep 30, 2019·Molecular Aspects of Medicine·Stefan WernerKlaus Pantel
Jan 17, 2020·F1000Research·Kathleen J GreenJoshua A Broussard
Dec 30, 2015·International Journal of Molecular Sciences·Sabita N SaldanhaTrygve O Tollefsbol
Jan 21, 2020·The Journal of Investigative Dermatology·Alyssa VetterThomas M Magin
May 20, 2020·Current Biology : CB·Kathleen J GreenScott A Nichols
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke

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