PMID: 9428928Jan 16, 1998Paper

Keratin subsets in papillary and follicular thyroid lesions. A paraffin section analysis with diagnostic implications

Virchows Archiv : an International Journal of Pathology
M MiettinenP Kärkkäinen

Abstract

Previous studies indicate that keratins 7, 8 and 18 are present in all thyroid papillary and follicular lesions, but the distribution of other keratins has been incompletely characterized. The profile of individual keratin (K) polypeptides was evaluated immunohistochemically in over 200 non-neoplastic and neoplastic thyroid papillary and follicular lesions. Monoclonal antibodies to K19, K17, K16, K5/6 and K10 were applied in paraffin sections of formaldehyde-fixed tissue. K19 was present variably, often only focally in goitres, and was present only sporadically in papillary hyperplasia. However, K19 was strongly and uniformly expressed in virtually all papillary carcinomas, indicating differential diagnostic usefulness in differentiating papillary hyperplasia and papillary carcinoma. About half of the follicular carcinomas (defined as tumours strictly excluding the follicular variant of papillary carcinoma) were also strongly K19-positive, suggesting that K19 patterns are not reliable in differentiating papillary and follicular carcinoma. K17 and K5/6 were present in cysts and squamous metaplasia of goitres, and focally in papillary but only exceptionally in follicular carcinoma in areas of squamous differentiation and tumour c...Continue Reading

Citations

Aug 19, 2007·Thyroid : Official Journal of the American Thyroid Association·Daniela CabibiFederico Aragona
Jun 23, 2012·The American Journal of Dermatopathology·Julie Y TseMai P Hoang
Jun 5, 2003·Journal of Clinical Pathology·C E Anderson, K M McLaren
May 15, 2013·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Fawaz M MakkiRobert D Hart
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