Keratinization of the sulcular epithelium--a pointless pursuit?

Journal of Periodontology
C A Squier

Abstract

A considerable amount of effort has been directed at finding methods for modifying the nonkeratinized sulcular epithelium on the assumption that a keratinized surface may offer a better barrier to antigens and bacterial products present in the gingival sulcus. It is argued here that keratinization in itself may not confer greater impermeability, for nonkeratinized epithelia also have been shown to resist the penetration of certain substances. Moreover, few workers have considered the role of junctional epithelium in the initiation of periodontal disease although experimental evidence suggests that this may be a permeable tissue. As formation of a surface with barrier properties seems to be a concomitant of epithelial differentiation while attachment is a property of relatively undifferentiated epithelial cells, attempts to induce junctional epithelium to differentiate could result in a loss of epithelial attachment to the tooth. It is suggested that attempts to keratinize the sulcular region, on theoretical grounds, may be unjustified.

References

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Citations

Aug 1, 1990·Journal of Clinical Periodontology·H R Haanaes
Jun 16, 2010·The Journal of Oral Implantology·Wael Aly Ghuneim
Aug 1, 1983·Acta Odontologica Scandinavica·E K KristoffersenT O Kristoffersen
Mar 1, 1997·Journal of Periodontology·T MatsuyamaT Sueda
Aug 26, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G Suchett-KayeO Barsotti
Mar 1, 1988·Journal of Periodontal Research·A W RomanowskiC A Lesch
Jan 1, 1994·Journal of Periodontal Research·J I Salonen
Nov 1, 1989·Journal of Periodontal Research·J I SalonenB A Dale
Mar 27, 2003·Periodontology 2000·Marja T PöllänenVeli-Jukka Uitto
Aug 1, 1986·Australian Dental Journal·P J HenryC D Wall
Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C A Squier

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