Keratinocyte differentiation is stimulated by activators of the nuclear hormone receptor PPARalpha

The Journal of Investigative Dermatology
K HanleyK R Feingold

Abstract

Peroxisome proliferator activated receptors (PPAR) belong to the superfamily of nuclear hormone receptors that heterodimerize with the retinoid X receptor and regulate transcription of several genes involved in lipid metabolism and adipocyte differentiation. Because of the role of 1,25-dihydroxyvitamin D3 and retinoic acid working through similar receptors (the vitamin D receptor and retinoic acid receptor, respectively) on keratinocyte differentiation, we have examined the effects of activators of PPARalpha on keratinocyte differentiation. The rate of cornified envelope formation was increased 3-fold in keratinocytes maintained in low calcium (0.03 mM) and incubated in the presence of clofibric acid, a potent PPARalpha activator. Involucrin, a cornified envelope precursor, and the cross-linking enzyme transglutaminase, were increased at both the message level (2-7-fold) and the protein level (4-12-fold) by clofibric acid. Furthermore, physiologic doses of the fatty acids oleic acid, linoleic acid, and eicosatetraynoic acid, which are also activators of PPARalpha, also induced involucrin and transglutaminase protein and mRNA. In contrast, the PPARgammaligand prostaglandin J2 had no effect on protein or mRNA levels of involucrin...Continue Reading

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Citations

Jul 16, 2005·Cell Death and Differentiation·D J KimJ M Peters
Dec 2, 2008·PPAR Research·David Bishop-Bailey, Karen E Swales
Jun 9, 2012·Cells, Tissues, Organs·Carmen ZhangBrian J Aneskievich
Jan 30, 2014·Anais Brasileiros De Dermatologia·Emerson de Andrade LimaMaira Galdino da Rocha Pita
Apr 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Casey L MoulsonJeffrey H Miner
Feb 26, 2000·The Journal of Investigative Dermatology·K HanleyK R Feingold
Aug 22, 2000·The Journal of Investigative Dermatology·L G KömüvesK R Feingold
Jan 8, 2004·The Journal of Investigative Dermatology·Majken WestergaardKarsten Kristiansen
Jun 12, 2004·The Journal of Investigative Dermatology·Diane Thiboutot
Jul 6, 2007·The Journal of Investigative Dermatology·Yan J JiangKenneth R Feingold
Aug 23, 2003·The British Journal of Dermatology·S Kuenzli, J-H Saurat
May 23, 2008·International Journal of Cosmetic Science·A V Rawlings
Mar 20, 2004·The British Journal of Dermatology·H Y KangW H Kang
Mar 25, 2000·The Journal of Investigative Dermatology·M RivierS Michel
Dec 22, 2004·The Journal of Investigative Dermatology·Anthony M FloresBrian J Aneskievich
Jul 13, 2004·The Journal of Investigative Dermatology·Man Mao-QiangKenneth R Feingold
Feb 20, 2002·The Journal of Investigative Dermatology·László G KömüvesKenneth R Feingold
Aug 23, 2005·Biochemical and Biophysical Research Communications·Mitsuo JisakaKazushige Yokota
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Aug 16, 2008·The Journal of Investigative Dermatology·Joachim W FluhrKenneth R Feingold
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Apr 12, 2002·International Journal of Cancer. Journal International Du Cancer·Nikolaos G NikitakisJohn J Sauk

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