PMID: 7528926Dec 20, 1994Paper

Keratinocyte expression of B7-1 in transgenic mice amplifies the primary immune response to cutaneous antigens

Proceedings of the National Academy of Sciences of the United States of America
I R WilliamsT S Kupper

Abstract

Resting epidermal keratinocytes do not express B7-1 and other known CD28 counterligands with costimulatory activity. The absence of these costimulators on keratinocytes correlates with their ability to preferentially induce T-cell anergy instead of T-cell activation. To test the hypothesis that keratinocytes expressing a CD28 counterligand would be more effective inducers of T-cell-mediated immune responses in skin, we prepared transgenic mice in which expression of the B7-1 costimulator was targeted to basal keratinocytes by using the human K14 promoter. Keratinocytes from the K14/B7-1 transgenic line expressed high levels of surface B7-1. No spontaneous inflammatory changes were seen in transgenic skin, but epicutaneous application of contact sensitizers to these mice elicited a stronger primary ear swelling response than in controls. Sites of initial hapten application in transgenic mice also responded much more strongly to reapplication of hapten to a remote cutaneous site. Epidermal cell suspensions from transgenic mice contained normal numbers of Langerhans cells and dendritic epidermal T cells when analyzed by flow cytometry. Systemic treatment of the transgenic mice with interferon gamma induced high levels of class II ...Continue Reading

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Citations

Jan 1, 1996·Life Sciences·I R Williams, T S Kupper
Jun 1, 1996·Immunology Today·H G OttenG C de Gast
Jun 1, 1995·Current Opinion in Immunology·D L Mueller, M K Jenkins
Oct 18, 2001·Clinics in Dermatology·N NajafianM H Sayegh
Jun 1, 1996·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·R P Burns, A A Gaspari
Jun 1, 1997·American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society·W P Jordan
Jan 14, 2012·Nature Reviews. Immunology·Daniel H KaplanAnthony A Gaspari
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·A MondinoM K Jenkins
Dec 31, 1997·The Journal of Clinical Investigation·P W CookM R Pittelkow
Sep 12, 2013·Clinical & Developmental Immunology·Matthias Peiser
Jun 4, 2004·Current Allergy and Asthma Reports·Clemens EscheLisa A Beck
Mar 29, 2003·Expert Opinion on Biological Therapy·Nader Najafian, Samia J Khoury
Apr 25, 2009·Genesis : the Journal of Genetics and Development·Michael S SamuelMichael F Olson
May 24, 2008·Immunology·Rocío Isabel Domínguez-CastilloWalid Kuri-Harcuch
Apr 6, 2005·Transplantation Proceedings·J LeiL Zhang
Jan 1, 1995·International Reviews of Immunology·S Guerder, R A Flavell
Apr 29, 1998·Clinical Immunology and Immunopathology·A A GaspariR K Barth
Mar 31, 2004·Scandinavian Journal of Immunology·G BanerjeeG Raman
Jul 17, 1998·The British Journal of Dermatology·Y Nakano
Jul 13, 2006·Annals of the New York Academy of Sciences·Marie B Demay
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J H ChoY C Sung
Sep 15, 2017·Journal of Oral Science·Alison MarshallStephen Porter
Apr 1, 1997·The Journal of Investigative Dermatology·J M CarrollF M Watt
Jul 1, 1995·The Journal of Investigative Dermatology·T S Kupper, R W Groves

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