Keratinocyte growth factor expression in human gingival fibroblasts and stimulation of in vitro gene expression by retinoic acid

Journal of Periodontology
I C Mackenzie, Z Gao

Abstract

Keratinocyte growth factor (KGF) is a stromally derived growth factor of the fibroblast growth factor (FGF) family with paracrine effects targeted to influence the growth and differentiation of epithelia. Regional and temporal changes in KGF expression play important roles in the development and maintenance of epithelial structures and in epithelial wound healing. Differing patterns of expression of KGF by fibroblasts in the gingival region could therefore be related to the observed regional variation in the differentiation and behavior of gingival epithelia. The in vitro and in vivo patterns of expression of KGF mRNA in human gingival and periodontal fibroblasts were examined using reverse transcription polymerase chain reactions (RT-PCR) and in situ hybridization with digoxigenin-labeled riboprobes. The patterns observed for human gingiva were compared with those for human skin and for murine tissues. Gingival and periodontal fibroblasts showed expression of KGF transcripts in vitro, and the degree of expression was markedly influenced by the presence of retinoic acid, an agent known to influence patterns of epithelial differentiation. Sections of human and murine gingiva and skin showed regionally variable expression of tran...Continue Reading

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Citations

Mar 21, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Birgitte GrønErik Dabelsteen
Mar 1, 2005·Journal of Periodontal Research·Min LiEdward E Putnins
Mar 22, 2005·Biochimica Et Biophysica Acta·Yoichiro TakamiEiichi Gohda
Feb 1, 2003·European Journal of Oral Sciences·Scott Thomas William McKeownChristopher Robert Irwin
Jul 9, 2003·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shun-Yao KoTsung-Yun Liu
Apr 17, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katarzyna M SitnikWilliam W Agace
Dec 8, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Laurent PlantierBruno Crestani

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