Keratinocyte integrins in wound healing and chronic inflammation of the human periodontium

Oral Diseases
H LarjavaV J Uitto

Abstract

Periodontal epithelium plays a critical role in protection, destruction and repair of human periodontium. During optimal repair, epithelium migrates and covers the wound surface to prevent infection and damage of the vulnerable underlying connective tissue. During periodontal destruction, junctional epithelium undergoes transformation to pocket epithelium that has quite different characteristics from junctional epithelium. In the course of periodontal disease the epithelial attachment to the tooth surface is lost and the epithelium proliferates and extends pseudo-rete ridges deep into the inflamed connective tissue. Both scenarios, repair and destruction, involve active epithelial migration either in the wound provisional matrix or in the inflamed connective tissue matrix, respectively. This review covers recent research data on cellular receptors, integrins, that mediate epithelial cell migration during wound healing and destruction of human periodontium.

References

May 1, 1992·Journal of Dental Research·V J UittoD M Brunette
May 1, 1992·The Journal of Cell Biology·A König, L Bruckner-Tuderman
Jun 1, 1992·The Journal of Clinical Investigation·M D HertleF M Watt
Mar 1, 1990·The Journal of Cell Biology·H LarjavaK M Yamada
Jun 1, 1991·The British Journal of Dermatology·E RalfkiaerG L Vejlsgaard
Nov 1, 1991·Journal of Cellular Physiology·S B MilamR J Klebe
Feb 1, 1991·The Journal of Clinical Investigation·G J GiudiceL A Diaz
Jun 1, 1991·Cell Regulation·J C JonesV Quaranta
Nov 1, 1990·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·U KonterW Sterry
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M A SteppI K Gipson
Jun 1, 1988·The Journal of Investigative Dermatology·J E OlerudG F Odland
Jul 1, 1988·Journal of Cellular Physiology·D T WoodleyE J O'Keefe
Jan 1, 1989·Archives of Dermatological Research·U KonterW Sterry
Aug 1, 1989·The Journal of Cell Biology·C Ffrench-ConstantR O Hynes
Jan 1, 1986·Journal of Periodontology·T K PengM J Levine
Oct 1, 1986·The Journal of Cell Biology·L Y SakaiR E Burgeson
Jan 1, 1968·Journal of Periodontal Research·H L FreedmanN S Taichman
Jan 1, 1970·Journal of Periodontal Research·J B Gavin
Oct 1, 1994·Current Opinion in Cell Biology·J Gailit, R A Clark
Aug 1, 1995·Experimental Cell Research·P J Jensen, M J Wheelock
Jul 1, 1995·The Journal of Investigative Dermatology·T HaapalainenT Salo
Apr 1, 1995·Molecular Biology of the Cell·U MüllerL F Reichardt
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A L PrietoK L Crossin
Apr 1, 1994·Matrix Biology : Journal of the International Society for Matrix Biology·R E BurgesonJ Sanes
Jul 1, 1994·Experimental Cell Research·J C JonesS B Hopkinson
Aug 1, 1994·The Journal of Investigative Dermatology·J GailitR A Clark

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Citations

Feb 1, 1997·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J JonesP M Speight
Apr 26, 2000·British Journal of Cancer·S HamidiH Larjava
Feb 16, 2002·Journal of Periodontology·Jaana Oksanen, Marketta Hormia
Feb 19, 2009·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Ameneh EslamiHannu S Larjava
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Kritika IyerChase S Linsley
Jan 25, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·G J Thomas, P M Speight
Jun 15, 2007·The International Journal of Lower Extremity Wounds·Magnus S Agren, Maria Werthén
Oct 1, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Robert A UnderwoodJohn E Olerud
May 7, 2015·Advances in Wound Care·Matthew P CaleyEdel A O'Toole
Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T KainulainenA Oikarinen
Mar 3, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A K ThorupE Dabelsteen
Mar 26, 2003·Plastic and Reconstructive Surgery·Sherry S CollawnJohn R Couchman
Apr 25, 2012·Cell and Tissue Research·Vera L MartinsEdel A O'Toole
Oct 5, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Nuzhat AhmedMark S Baker
May 11, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·B SteffensenH Larjava
Jun 8, 2017·Cancers·Hanadi Talal AhmedahHelen M Sheldrake
Mar 24, 1998·Oral Oncology·G J ThomasP M Speight
Jul 10, 2001·The Journal of Investigative Dermatology·G J ThomasJ F Marshall
Jun 1, 1997·The Journal of Investigative Dermatology·L T Kim, K M Yamada
Dec 21, 2006·Differentiation; Research in Biological Diversity·Mariana Roesch-ElyPascal Tomakidi

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