Keratinocyte stem cells, label-retaining cells and possible genome protection mechanisms

The Journal of Investigative Dermatology. Symposium Proceedings
C S Potten

Abstract

Stem cells are the crucial cells upon which the entire tissue is dependent. Here we define and discuss what is meant by and known about keratinocyte stem cells. One way in which these cells have been studied is by their ability to retain radioactivity labelled thymidine for long periods of time (label retaining cells, LRCs). The underlying mechanism has been assumed in the past to be slow cycling but a more likely explanation is the selective segregation of old and new DNA strands (Cairns's hypothesis). Experiments in the small intestine indicate that the stem cells here are selectively sorting their DNA and becoming LRCs. A possible role for p53 in stem cell biology is presented.

References

Nov 1, 1978·Cell·C S PottenJ Cairns
Aug 11, 1975·Differentiation; Research in Biological Diversity·C S Potten, T D Allen
Jul 2, 1992·Nature·D P Lane
Jan 1, 1985·Cell and Tissue Research·I C Mackenzie, J R Bickenbach
Mar 1, 1971·The Journal of Investigative Dermatology·E Christophers
Oct 1, 1971·The Journal of Investigative Dermatology·E Christophers
Jan 1, 1981·International Review of Cytology·C S Potten
Aug 1, 1981·Journal of Dental Research·J R Bickenbach
Jul 1, 1993·The Journal of Investigative Dermatology·R M LavkerT T Sun
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·K KobayashiY Barrandon
May 1, 1996·Nature Medicine·T NorimuraS Kondo
Dec 1, 1996·British Journal of Cancer·C S Potten
Aug 1, 1997·International Journal of Experimental Pathology·C S PottenD M Pritchard
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·A LiP Kaur
Jul 31, 1998·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C S Potten
Apr 14, 1999·The Journal of Investigative Dermatology·R J Morris, C S Potten
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·H TaniP Kaur
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M Lavker, T T Sun
Jan 10, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Emma MarshmanChristopher S Potten
Apr 27, 2002·Nature·Emi K NishimuraShin-Ichi Nishikawa
Oct 31, 2002·The Journal of Investigative Dermatology·Christopher S Potten, Catherine Booth
Mar 22, 2003·The Journal of Investigative Dermatology·Carol S TrempusRaymond W Tennant
Jun 20, 2003·Cell Proliferation·Christopher S PottenDanielle Hargreaves
Mar 17, 2004·Nature Biotechnology·Rebecca J MorrisGeorge Cotsarelis

❮ Previous
Next ❯

Citations

Nov 28, 2012·Development Genes and Evolution·Heiner Grandel, Michael Brand
Oct 28, 2010·Protoplasma·Alessio PapiniLuigi Brighigna
Jul 13, 2007·Stem Cell Reviews·Kristin M Braun, David M Prowse
May 5, 2011·Nature Cell Biology·Elaine Fuchs, Valerie Horsley
May 5, 2006·Molecular Biology of the Cell·Sarah L CrittendenJudith Kimble
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·E Fuchs, J A Nowak
Jan 4, 2012·Photochemistry and Photobiology·Ashok SinghRebecca J Morris
Jan 3, 2012·Oncology Reports·Hongbo ZhangCaiping Ren
Jun 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Enzo Di IorioMichele De Luca
Jul 12, 2011·Stem Cell Reviews and Reports·Vasily V TerskikhEkaterina A Vorotelyak
Jul 20, 2010·Biologicals : Journal of the International Association of Biological Standardization·Sasirekha KrishnanSubramanian Krishnakumar
Mar 18, 2006·The Journal of Investigative Dermatology·Pritinder Kaur
Nov 21, 2007·Seminars in Cell & Developmental Biology·Ramkumar Sambasivan, Shahragim Tajbakhsh
May 9, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L E Finlan, T R Hupp
Dec 21, 2004·Differentiation; Research in Biological Diversity·Rebecca J Morris
Aug 26, 2016·The Journal of Comparative Neurology·James E SchwobJulie Hewitt Coleman
May 26, 2012·Circulation Research·Piero AnversaJan Kajstura
Nov 19, 2018·Development, Growth & Differentiation·Hironobu FujiwaraRitsuko Morita
Jun 5, 2010·Annals of Dermatology·Sung-Eun ChangSang Yoon Kim
Mar 2, 2019·Critical Reviews in Clinical Laboratory Sciences·Stella K Vasiliou, Eleftherios P Diamandis
Nov 24, 2012·Journal of Cosmetic Dermatology·Mark V Dahl
Feb 25, 2006·Science·Athanasios Armakolas, Amar J S Klar
Mar 8, 2020·Cellular and Molecular Gastroenterology and Hepatology·Paula S Montenegro-MirandaVanesa Muncan
Oct 4, 2005·Developmental Cell·Maranke I Koster, Dennis R Roop

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Investigative Dermatology. Symposium Proceedings
P KaurIvan Bertoncello
The Journal of Investigative Dermatology. Symposium Proceedings
Kristin M Braun, F M Watt
© 2021 Meta ULC. All rights reserved