Jan 1, 1989

Keratinocytes in lesional skin of atopic eczema bear HLA-DR, CD1a and IgE molecules

Clinical and Experimental Dermatology
T BieberO Braun-Falco

Abstract

Apparently normal, and lesional skin from patients with atopic eczema were investigated immunohistochemically with anti-HLA-DR, -CD1a and -IgE antisera. A CD1a+ intercellular pattern was observed in uninvolved skin in the majority of the patients whereas an HLA-DR+/CD1a+ network, mostly localized in basal and supra-basal areas, was shown in lesional skin of virtually all of them. Moreover, an HLA-DR+/CD1a+IgE+ intercellular pattern was observed in some of the patients only and was predominantly localized in those areas characterized by lymphocyte exocytosis, spongiosis or vesicle formation. Whether keratinocytes are able to synthesize CD1a antigen and Fc epsilon R or if these molecules are only produced and shed by CD1a+/IgE+ epidermal dendritic cells remains unclear.

  • References6
  • Citations16
  • References6
  • Citations16

Citations

Mentioned in this Paper

Membrane Budding
Dermatitis, Atopic
Leukocyte Differentiation Antigens, Human
Keratinocyte
CD1a antigen
Immune Sera
Immunoglobulin E
HLA-DR Antigens
Skin
Exocytosis

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