Abstract
Apparently normal, and lesional skin from patients with atopic eczema were investigated immunohistochemically with anti-HLA-DR, -CD1a and -IgE antisera. A CD1a+ intercellular pattern was observed in uninvolved skin in the majority of the patients whereas an HLA-DR+/CD1a+ network, mostly localized in basal and supra-basal areas, was shown in lesional skin of virtually all of them. Moreover, an HLA-DR+/CD1a+IgE+ intercellular pattern was observed in some of the patients only and was predominantly localized in those areas characterized by lymphocyte exocytosis, spongiosis or vesicle formation. Whether keratinocytes are able to synthesize CD1a antigen and Fc epsilon R or if these molecules are only produced and shed by CD1a+/IgE+ epidermal dendritic cells remains unclear.
References
Oct 1, 1986·The British Journal of Dermatology
Dec 1, 1986·The Journal of Investigative Dermatology·M C de JongS Poppema
Jan 1, 1987·Archives of Dermatological Research·C PicutR Lewis
Jan 1, 1986·Archives of Dermatological Research·C Bruynzeel-KoomenP L Bruynzeel
Jan 1, 1988·The Journal of Investigative Dermatology·L J Walsh, G J Seymour
Dec 1, 1985·The British Journal of Dermatology·R WillemzeW M Nugteren
Feb 1, 1982·The Journal of Investigative Dermatology·V B MorhennG Mahrle
Aug 1, 1984·The Journal of Investigative Dermatology·T Y BashamV B Morhenn
Sep 1, 1984·The British Journal of Dermatology·S Aiba, H Tagami
Feb 1, 1983·The Journal of Investigative Dermatology·T J HarristA K Bhan
Apr 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·E FithianR Edelson
Feb 1, 1982·The Journal of Investigative Dermatology·A ChuR L Edelson
Citations
Feb 25, 1992·Immunology Letters·J HunyadiA Dobozy
Dec 1, 1993·Journal of Dermatological Science·J T ElderP A Bleicher
Dec 31, 1996·Veterinary Parasitology·B L StemmerP F Moore
Feb 15, 2000·Clinical and Experimental Dermatology·L Skov, O Baadsgaard
Jan 1, 1995·The British Journal of Dermatology·V JanssensH Degreef
May 1, 1994·International Journal of Dermatology·G S WoodR A Warnke
Nov 1, 1990·Postgraduate Medical Journal·M H Rustin
Jul 6, 2000·The Journal of Clinical Investigation·A TrautmannC A Akdis
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael R Ardern-JonesGraham S Ogg
Jan 6, 2012·The Journal of Investigative Dermatology·Danuta Gutowska-Owsiak, Graham S Ogg
Jan 22, 2008·The British Journal of Dermatology·M R Ardern-JonesG S Ogg
Mar 4, 2008·Journal of Cutaneous Pathology·Mahmoud R Hussein
Aug 12, 2014·Microbes and Infection·Bao-Ping TianSongmin Ying
Apr 11, 2000·The Journal of Allergy and Clinical Immunology·L SkovD Y Leung
Jan 20, 1999·The Journal of Allergy and Clinical Immunology·R BunikowskiH Renz
Nov 13, 2001·The British Journal of Dermatology·T ZuberbierB M Henz