PMID: 7543441Aug 1, 1995Paper

Keratins 7 and 20 as diagnostic markers of carcinomas metastatic to the ovary

Human Pathology
C C WautersF C Ramaekers

Abstract

The most common carcinomas metastatic to the ovary that mimic ovarian primaries are colonic adenocarcinomas and endometrial carcinomas. Conventional histochemical staining procedures, even in combination with additional immunohistochemical assays, are of limited value in distinguishing between these metastases and primary ovarian carcinomas. In this study we investigated whether the application of monoclonal antibodies against keratins 7, 8, and 20 could help in differentiating between these categories. The reactivity patterns of 40 carcinomas metastatic to the ovary were compared with those of their primary carcinomas on the one hand and with various primary ovarian carcinomas and mesotheliomas on the other. Colon cancer metastatic to the ovary was keratin 7 negative and keratin 20 positive in 94% of the cases; in contrast, all primary ovarian carcinomas were keratin 7 positive and keratin 20 negative, with the exception of two cases of mucinous cystadenocarcinoma. Ovarian metastases of gastric cancer usually contained keratins 7 and 20. Metastases of endometrial cancer to the ovary and primary ovarian carcinomas usually showed similar keratin expression. We propose that keratin 7 and 20 antibodies may be of help to distinguis...Continue Reading

References

Jun 15, 1989·International Journal of Cancer. Journal International Du Cancer·C C van NiekerkL G Poels
Mar 1, 1983·The Journal of Clinical Investigation·F C RamaekersP H Jap
May 1, 1984·Cancer·M T MazurD J Gersell
Mar 1, 1984·Cancer·T M UlbrightF B Stehman

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Citations

Jul 13, 2000·Journal of Clinical Pathology·W G McCluggage
Nov 26, 2010·World Journal of Surgical Oncology·Yoshinaga OkugawaMasato Kusunoki
Nov 18, 2014·Case Reports in Obstetrics and Gynecology·Sung-Hee KimWon-Ho Edward Park
Sep 4, 2012·Human Pathology·Ross James TalianoMurray B Resnick
Apr 17, 2009·American Journal of Clinical Pathology·Robin T Vollmer
Mar 31, 2006·The Kaohsiung Journal of Medical Sciences·Yue-Chiu SuChee-Yin Chai
Jul 3, 2013·Journal of Gastroenterology and Hepatology·Hidetsugu YamagishiYoshihiko Ueda
Nov 12, 2005·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·R Shane TubbsW Jerry Oakes
Feb 2, 2011·Pathology, Research and Practice·Reyhan BayrakHacer Haltas
Feb 11, 2015·Oncology Letters·Qian LiuRen-Hua Guo
Feb 23, 2013·Human Pathology·Nelson G Ordóñez
Dec 6, 2000·Gynecologic Oncology·Y M ChanL C Wong
Jul 16, 2003·The American Journal of the Medical Sciences·Jonathan E Dowell
Mar 24, 2000·The British Journal of Dermatology·T Ohnishi, S Watanabe
Aug 17, 2005·American Journal of Clinical Pathology·Geza Acs
Sep 28, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·D H ShenA N Cheung
Aug 10, 2004·Archives of Gynecology and Obstetrics·Yu Sakai, Ben Hatano
May 20, 1999·Veterinary Pathology·A Espinosa de los MonterosJ Martín de las Mulas
Sep 28, 2002·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Hongxiu JiBrigitte M Ronnett
Dec 10, 2003·Applied Immunohistochemistry & Molecular Morphology : AIMM·Paul J ZhangJohn J Brooks
Dec 18, 2003·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tibor Tot, Siri Samii
Jun 6, 2002·American Journal of Clinical Pathology·Helen P Cathro, Mark H Stoler
Jan 31, 2012·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Hokuto TakamiWataru Yasui
Sep 10, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Maria Rosaria RaspolliniGian Luigi Taddei
Mar 17, 2005·World Journal of Gastroenterology : WJG·Bo SongLei Sun
May 16, 2002·Histopathology·P G Chu, L M Weiss

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