Keratins as markers of differentiated taste cells of the rat

Differentiation; Research in Biological Diversity
L KnappC Zhang

Abstract

Cytokeratins in taste buds were immunocytochemically evaluated with monoclonal antibodies. In each of six different epithelial sites in the rat oral cavity, intragemmal cells of taste buds were immunoreactive for keratin polypeptides 8, 18, and 19, as well as for keratin 7, which has not been previously reported in taste buds. Keratin-18-like immunoreactivity was present in fewer than half of the intragemmal cells, whereas all intragemmal cells were immunopositive for keratins 7, 8, and 19. Apart from some salivary duct cells, no other cells in the tongue were immunoreactive for any of these four keratins. Morphological and immunocytochemical profiles indicate that taste buds are islets of simple epithelium embedded in an expanse of stratified squamous epithelium. These simple epithelial cells and their keratins are nerve-dependent, since denervation eliminated all four keratins and replaced elongated taste cells of the vallate papilla with stratified squamous epithelium. We conclude that antibodies against keratins 7, 8, or 19 are useful markers for intragemmal cells in studies of taste bud development, degeneration, regeneration, turnover and tissue culture.

References

Oct 1, 1990·The American Journal of Anatomy·M H SawafN Forest
Jan 1, 1991·Histochemistry·W KuijpersF C Ramaekers
Sep 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L K Barthel, P A Raymond
Jan 1, 1985·Annals of the New York Academy of Sciences·R A QuinlanW W Franke
Jan 1, 1985·Annals of the New York Academy of Sciences·T T SunR Eichner
Jan 1, 1986·Cell Motility and the Cytoskeleton·O Gigi-Leitner, B Geiger
May 1, 1987·Experimental Cell Research·F RamaekersP Vooijs
Nov 1, 1982·The Journal of Cell Biology·J Woodcock-MitchellT T Sun
Jan 1, 1982·Cold Spring Harbor Symposia on Quantitative Biology·W W FrankeK Illmensee
Apr 16, 1993·Brain Research. Developmental Brain Research·B Oakley

❮ Previous
Next ❯

Citations

Aug 28, 1999·The Journal of Comparative Neurology·Q Zeng, B Oakley
Aug 13, 1998·The Anatomical Record·G M Nelson
Dec 1, 1995·The Histochemical Journal·Q ZengB Oakley
Jul 25, 2009·Cell and Tissue Research·Akira Ito, Christopher A Nosrat
Oct 26, 2007·Journal of Molecular Histology·Misaki Asano-MiyoshiYasufumi Emori
Oct 12, 2005·Journal of Neurocytology·Bruce Oakley, Martin Witt
Oct 3, 2008·In Vitro Cellular & Developmental Biology. Animal·Xiaoyan LuoBrigid L M Hogan
Mar 13, 1998·Brain Research. Developmental Brain Research·D Cooper, B Oakley
Mar 13, 1998·Brain Research. Developmental Brain Research·B OakleyC Zhang
Oct 1, 1995·Differentiation; Research in Biological Diversity·C ZhangQ Zeng
Dec 1, 1996·Differentiation; Research in Biological Diversity·C Zhang, B Oakley
Oct 4, 2006·Genes & Development·Tadashi OkuboBrigid L M Hogan
Feb 4, 1999·Annals of the New York Academy of Sciences·B Oakley
Sep 3, 2011·Zoological Science·Miyako NishiyamaYasuhiro Tomooka
Oct 11, 2014·Cell and Tissue Research·Alexandra Regina PanneckWolfgang Kummer
Dec 22, 2004·The Journal of Comparative Neurology·R Glenn Northcutt
Dec 22, 2015·Journal of Chemical Neuroanatomy·Ahmed RashwanHiroshi Kiyama
Nov 18, 2008·Acta histochemica·Yu-Mei QinTeng-Hao Wang
Jul 13, 2007·The Journal of Comparative Neurology·Nick A Guagliardo, David L Hill
Jun 9, 2010·The European Journal of Neuroscience·Jeremy M SullivanSharon Oleskevich
Aug 7, 2004·Human Pathology·Asterios Triantafyllou, Philip Coulter
Aug 7, 2013·Developmental Biology·Hong Xiang LiuCharalotte M Mistretta
May 29, 2014·Acta Odontologica Scandinavica·Jui-Chin HsuTakashi Ono
Sep 19, 2016·Biochemical and Biophysical Research Communications·Nandakumar VenkatesanHong-Xiang Liu
Nov 29, 2016·PLoS Genetics·Alexandre N ErmilovCharlotte M Mistretta
Jan 1, 2016·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Joto YoshimotoTakumi Misaka
Feb 14, 2008·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·John GardinerRobyn Overall
Nov 15, 2017·Proceedings of the National Academy of Sciences of the United States of America·Archana KumariCharlotte M Mistretta
Jul 27, 2017·Development·David Castillo-AzofeifaLinda A Barlow
Oct 12, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lynnette Phillips McCluskey, David L Hill
Jan 24, 2003·The Journal of Comparative Neurology·Linda A Barlow
Jun 16, 2000·Physiology & Behavior·J R Ganchrow

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.