Keratoacanthoma: a clinico-pathologic enigma
Keratoacanthoma (KA) is an extraordinary entity. Once considered a benign neoplasm that resembled a highly malignant one (pseudomalignancy), it is now viewed in an opposite light as a cancer that resembles a benign neoplasm (pseudobenignity). The goal was to delineate the malignant potential of this neoplasm based on the author's experience and a review of recent data and research and to emphasize the KA as a possible part of an autosomal dominant familial cancer syndrome, the Muir-Torre syndrome. This is a review of the literature. In this work, the KA is reviewed with recent advances emphasized. KA is an abortive malignancy that rarely progresses into an invasive SCC. The KA may serve as a marker for the important autosomal dominant familial cancer syndrome, the Muir-Torre syndrome, as a result of a defective DNA mismatch repair gene.
Evidence that regression in keratoacanthoma is immunologically mediated: a comparison with squamous cell carcinoma
Relative amounts of keratin 17 are higher than those of keratin 16 in hair-follicle-derived tumors in comparison with nonfollicular epithelial skin tumors
Differential diagnosis of keratoacanthomas and squamous cell carcinomas: diagnostic value of DNA image cytometry and p53 expression
Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry
Keratoacanthoma versus squamous cell carcinoma. An immunohistochemical reappraisal of p53 protein and proliferating cell nuclear antigen expression in keratoacanthoma-like tumors
Patterns of cell proliferation in actinic keratoacanthomas and squamous cell carcinomas of the skin. Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections
Loss of heterozygosity analysis of keratoacanthoma reveals multiple differences from cutaneous squamous cell carcinoma
Synchronous appearance of keratoacanthomas in burn scar and skin graft donor site shortly after injury
Identification of DNA sequences of both genital and cutaneous HPV types in a small number of keratoacanthomas of nonimmunosuppressed patients
Differentiating squamous cell carcinoma from keratoacanthoma using histopathological criteria. Is it possible? A study of 296 cases
Intralesional methotrexate as effective treatment in solitary giant keratoacanthoma of the lower lip
Intralesional methotrexate injection: an effective time and cost saving therapy alternative in keratoacanthomas that are difficult to treat surgically
Differences between squamous cell carcinoma and keratoacanthoma in angiotensin type-1 receptor expression
The level of syndecan-1 expression is a distinguishing feature in behavior between keratoacanthoma and invasive cutaneous squamous cell carcinoma
Microsatellite instability and immunostaining for MSH-2 and MLH-1 in cutaneous and internal tumors from patients with the Muir-Torre syndrome
Nine-year follow-up of a case of Grzybowski type multiple keratoacanthomas and failure to demonstrate human papillomavirus
Intralesional corticosteroid treatment of multiple eruptive keratoacanthomas: case report and review of a controversial therapy
Generalized eruptive keratoacanthoma of Grzybowski: follow-up of the original description and 50-year retrospect
Keratoacanthomas frequently show chromosomal aberrations as assessed by comparative genomic hybridization
VCAM (CD-106) and ICAM (CD-54) adhesion molecules distinguish keratoacanthomas from cutaneous squamous cell carcinomas
Keratoacanthoma developing in sites of previous trauma: a report of two cases and review of the literature
A comparative morphological study of the kerato-acanthoma of man and similar experimentally produced lesions in the rabbit
The role of the hair follicle in the origin and evolution of some cutaneous neoplasms of man and experimental animals
Eruptive self-resolving keratoacanthomas developing after treatment with photodynamic therapy and microdermabrasion
Combined 5-fluorouracil and Er:YAG laser treatment in a case of recurrent giant keratoacanthoma of the lower leg
Clinical manifestations of cutaneous metastases: a review with special emphasis on cutaneous metastases mimicking keratoacanthoma
Multiple reactive keratoacanthomas in a patient with hypertrophic lichen planus treated with cyclosporine: successful treatment with acitretin
Array comparative genomic hybridization of keratoacanthomas and squamous cell carcinomas: different patterns of genetic aberrations suggest two distinct entities
Eruptive keratoacanthoma following topical imiquimod for in situ squamous cell carcinoma of the skin in a renal transplant recipient
Multiple keratoacanthomas in a young woman: report of a case emphasizing medical management and a review of the spectrum of multiple keratoacanthomas
The Bcl-xL inhibitor of apoptosis is preferentially expressed in cutaneous squamous cell carcinoma compared with that in keratoacanthoma
Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: classification and identification
The changes in the expression levels of follicular markers in keratoacanthoma depend on the stage: keratoacanthoma is a follicular neoplasm exhibiting infundibular/isthmic differentiation without expression of CK15
Expression of cell cycle and apoptosis regulatory proteins in keratoacanthoma and squamous cell carcinoma
Interpreting epithelial cancer biology in the context of stem cells: tumor properties and therapeutic implications
Intralesional methotrexate for the treatment of keratoacanthoma: retrospective study and review of the korean literature
Expression of apoptosis-inducing factor (AIF) in keratoacanthomas and squamous cell carcinomas of the skin
The novel protein PTPIP51 is expressed in human keratinocyte carcinomas and their surrounding stroma.
Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report.
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