PMID: 14871228Feb 12, 2004

Keratoacanthoma: a clinico-pathologic enigma

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Robert A Schwartz

Abstract

Keratoacanthoma (KA) is an extraordinary entity. Once considered a benign neoplasm that resembled a highly malignant one (pseudomalignancy), it is now viewed in an opposite light as a cancer that resembles a benign neoplasm (pseudobenignity). The goal was to delineate the malignant potential of this neoplasm based on the author's experience and a review of recent data and research and to emphasize the KA as a possible part of an autosomal dominant familial cancer syndrome, the Muir-Torre syndrome. This is a review of the literature. In this work, the KA is reviewed with recent advances emphasized. KA is an abortive malignancy that rarely progresses into an invasive SCC. The KA may serve as a marker for the important autosomal dominant familial cancer syndrome, the Muir-Torre syndrome, as a result of a defective DNA mismatch repair gene.

References

Dec 1, 1979·Journal of Surgical Oncology·R A Schwartz
Jan 1, 1979·The British Journal of Dermatology·A Rook, I Whimster
Jan 1, 1979·Oncology·R A Schwartz
Jan 1, 1991·Clinical and Experimental Dermatology·S M WilkinsonA G Smith
May 11, 1991·British Dental Journal·G HabelK Donath
Nov 1, 1990·Journal of the American Academy of Dermatology·J C ShawE Everts
Feb 1, 1990·The American Journal of Dermatopathology·G Kannon, H K Park
Nov 1, 1990·Journal of the American Academy of Dermatology·M L StreetL E Gibson
Jun 1, 1990·The Journal of Dermatologic Surgery and Oncology·L RequenaE Sánchez Yus
Jan 1, 1986·The British Journal of Dermatology·E Blitstein-WillingerG Stüttgen
Mar 8, 1969·Lancet·I T Jackson
Oct 1, 1993·Journal of Cutaneous Pathology·P Phillips, K F Helm
Jul 1, 1995·Journal of the American Academy of Dermatology·R A Schwartz, D P Torre
Aug 1, 1995·Journal of the American Academy of Dermatology·R A Schwartz
Dec 1, 1994·Journal of Cutaneous Pathology·J P SleaterJ B Hendricks
Jan 1, 1995·Journal of the American Academy of Dermatology·R A Schwartz
Dec 1, 1994·Journal of the American Academy of Dermatology·E G Kuflik
Aug 1, 1993·The American Journal of Dermatopathology·E HodakA B Ackerman
Jan 1, 1994·Journal of the American Academy of Dermatology·R A Schwartz
Aug 1, 1995·The American Journal of Dermatopathology·A BorkowskiB F Trump
Mar 1, 1997·Archives of Dermatological Research·K PerisS Chimenti
May 1, 1997·Journal of the American Academy of Dermatology·R C GrineK E Greer
Jan 1, 1997·Dermatology : International Journal for Clinical and Investigative Dermatology·R OkuyamaH Tagami
Feb 20, 1999·Archives of Dermatological Research·N LangenbachW Stolz
Apr 28, 1999·The American Journal of Dermatopathology·P AschB Cribier
May 13, 1999·Journal of the American Academy of Dermatology·G TamirD J Hauben
May 15, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·E StockflethT Meyer
Jun 29, 1999·Aesthetic Plastic Surgery·G M BeerV E Meyer
Aug 18, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·M AgarwalR Walia
Sep 22, 1999·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·A GewirtzmanH Rabinovitz
Dec 11, 1999·Dermatology : International Journal for Clinical and Investigative Dermatology·B CribierE Grosshans
Feb 25, 2000·Journal of the American Academy of Dermatology·W HuN S Penneys
Apr 29, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·T A TranJ A Carlson
May 2, 2000·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·B Somlai, P Holló
Jul 15, 2000·Dermatology : International Journal for Clinical and Investigative Dermatology·K SpiethR Kaufmann
Aug 19, 2000·The American Journal of Dermatopathology·E Sánchez YusE de Eusebio
Jun 1, 1997·The Australasian Journal of Dermatology·J J Sullivan
Sep 21, 2000·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·R RemlingJ Ring
Mar 30, 2001·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·R BaranB Richert
Aug 8, 2001·The Australasian Journal of Dermatology·A M GodboltD Weedon
Dec 12, 2001·The British Journal of Dermatology·M KarakasH R Memisoğlu
Jan 18, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Perkins MukunyadziBruce R Smoller
Apr 30, 2002·The American Journal of Dermatopathology·Philip E LeBoit
Nov 2, 2002·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Scott SandersKishwer S Nehal
Nov 22, 2002·Dermatology : International Journal for Clinical and Investigative Dermatology·Robert A SchwartzStefania Jablonska
Dec 18, 2002·The Journal of Investigative Dermatology·Ole Petter F ClausenPaula M de Angelis
Jan 16, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Nicole D MelendezMichael Morgan
Feb 4, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·SueEllen Cox
Feb 13, 2003·Journal of the American Academy of Dermatology·Sean F Pattee, Nancy G Silvis
Feb 13, 2003·Journal of the American Academy of Dermatology·Yumie OgasawaraMasahiko Muto
Jan 1, 1959·The Journal of Pathology and Bacteriology·F N GHADIALLY
May 1, 1963·Cancer·F N GHADIALLYD F KERRIDGE
Jul 1, 1950·The British Journal of Dermatology and Syphilis·M GRZYBOWSKI

Citations

Jul 30, 2008·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·M NiebuhrT Werfel
Mar 27, 2009·HNO·M Braun-Falco
Dec 6, 2005·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·U B Kottler, A Bergua
Mar 25, 2008·The American Journal of Dermatopathology·Steven KossardCarolyn Choy
Oct 15, 2013·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Ravinder GogiaKanade Shinkai
Dec 21, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jens J ThielePeter Elsner
Mar 19, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Adam J MamelakPaul M Friedman
Sep 18, 2009·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Jason C HadleyMichael L Hadley
Aug 23, 2005·The British Journal of Ophthalmology·Igal LeibovitchDinesh Selva
Mar 17, 2012·Indian Journal of Dermatology, Venereology and Leprology·Maria M FariasSergio Gonzalez
Aug 27, 2013·Indian Journal of Dermatology, Venereology and Leprology·Ramesh M BhatSumanth Devaraju
Oct 14, 2014·Diseases·Katherine N Gibson-CorleyDavid K Meyerholz
Jul 19, 2014·Indian Journal of Dermatology, Venereology and Leprology·Maria Letizia MusumeciGiuseppe Micali
Feb 20, 2016·Journal of the American Academy of Dermatology·Ann M John, Robert A Schwartz
Feb 9, 2016·Journal of the American Academy of Dermatology·Bartlomiej Kwiek, Robert A Schwartz
Oct 22, 2011·Clinics in Dermatology·Jennifer L DePryJerry D Brewer
Oct 15, 2011·Journal of the American Academy of Dermatology·Ulrike WielandAlexander Kreuter
Nov 26, 2009·The Medical Clinics of North America·Carlos RicottiClay J Cockerell
Jan 2, 2010·Seminars in Diagnostic Pathology·Joshua C Mandrell, Daniel Santa Cruz
Aug 25, 2009·Journal of the American Academy of Dermatology·Eun Ji KwonChristine Jaworsky
Jan 6, 2009·Journal of the American Academy of Dermatology·Amanda Marcollo PiniGünther F L Hofbauer
Nov 9, 2005·Skinmed·Philip R CohenBruce R Nelson
May 24, 2008·Journal of the European Academy of Dermatology and Venereology : JEADV·C S SouzaV S Bagnato
Jul 7, 2007·International Journal of Dermatology·Amel Karaa, Amor Khachemoune
Jan 24, 2009·International Journal of Cancer. Journal International Du Cancer·Natasa VasiljevićOla Forslund
Mar 17, 2007·Clinical & Experimental Ophthalmology·Vanessa LimawararutDinesh Selva
Jun 2, 2011·International Journal of Cancer. Journal International Du Cancer·Johanna EkströmJoakim Dillner
Mar 19, 2011·International Journal of Dermatology·Victoria L WilliamsDavid J Stewart
Aug 8, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·A NofalM Alradi
Jul 30, 2014·International Journal of Dermatology·Ahmad NofalAyman Yosef
Dec 10, 2014·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Vivian Petersen WagnerCristiane Helena Squarize
Jun 20, 2006·Pathology, Research and Practice·Tanja BatinacGordana Zauhar
Jun 25, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Alexandre de Andrade SousaBruno Correia Jham
Aug 17, 2004·British Journal of Plastic Surgery·Richard W Griffiths
Jun 21, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Tasnuva HaqueMajella E Lane
Mar 4, 2017·The Journal of Dermatology·Toshihiro Takai
May 26, 2009·Journal of Applied Oral Science : Revista FOB·Lara Maria A RamosAntônio Francisco Durighetto-Júnior
Sep 13, 2011·Annals of Dermatology·Hye Chan JeonKwang Hyun Cho
Mar 14, 2019·Dermatologic Therapy·Norbert KissNorbert Wikonkál
Mar 18, 2011·Experimental Dermatology·Angelos SkyrlasIoannis D Bassukas
Nov 18, 2008·Journal of Cellular and Molecular Medicine·P KochM Wimmer
Aug 10, 2016·Cancer Research·Jun-Han LeeJoseph H Jeong

Related Concepts

Keratoacanthoma
Dermatologic Disorders

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

British Journal of Plastic Surgery
Richard W Griffiths
International Journal of Dermatology
Amel Karaa, Amor Khachemoune
The American Journal of Dermatopathology
Philip E LeBoit
Journal of Cutaneous Pathology
Ola ForslundOle Petter F Clausen
© 2021 Meta ULC. All rights reserved